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首页> 美国卫生研究院文献>Proceedings of the National Academy of Sciences of the United States of America >Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis.
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Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis.

机译：静脉注射可溶性抗原诱导胸腺和外周T细胞凋亡。

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摘要

The mechanism by which tolerance is induced via systemic administration of high doses of aqueous antigen has been analyzed by using mice transgenic for a T-cell receptor specific for the influenza virus hemagglutinin (HA) peptide comprising amino acids 126-138. After intravenous injection of 750 (but not 75) micrograms of HA peptide, a state of hyporesponsiveness was rapidly induced. In the thymus, in situ apoptosis in the cortex and at the corticomedullary junction was responsible for a synchronous and massive deletion of CD4+ CD8+ thymocytes. In secondary lymphoid organs, HA-reactive T cells were initially activated but were hyporesponsive at the single cell level. After 3 days, however, those cells were rapidly deleted, at least partially, through an apoptotic process. Therefore, both thymic and peripheral apoptosis, in addition to T-cell receptor desensitization, contribute to high-dose tolerance.
机译：已经通过使用转基因小鼠的T细胞受体的转基因小鼠，通过全身施用高剂量的水性抗原诱导耐受性的机制，所述T细胞受体对包含氨基酸126-138的流感病毒血凝素（HA）肽具有特异性。静脉注射750（而不是75）微克HA肽后，迅速诱发低反应状态。在胸腺中，皮质和皮质髓质交界处的原位凋亡是导致CD4 + CD8 +胸腺细胞同步大量缺失的原因。在次级淋巴器官中，HA反应性T细胞最初被激活，但在单细胞水平上反应低下。然而，三天后，那些细胞通过凋亡过程被至少部分地迅速缺失。因此，除了T细胞受体脱敏外，胸腺和外周细胞凋亡均有助于高剂量耐受性。

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