Intravenous injection of soluble antigen induces thymic and peripheral T-cell apoptosis

Roland S. Liblau; Roland Tisch; Kevan Shokat

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Intravenous injection of soluble antigen induces thymic and peripheral T-cell apoptosis

【24h】

Intravenous injection of soluble antigen induces thymic and peripheral T-cell apoptosis

机译：静脉注射可溶性抗原诱导胸腺和外周T细胞凋亡

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The mechanism by which tolerance is in- duced via systemic administration of high doses of aqueous antigen has been analyzed by using mice transgenic for a T-cell receptor specific for the influenza virus hemagglutinin (HA) peptide comprising amino acids 126-138. After intravenous injection of 750 (but not 75) μg of HA peptide, a state of hyporesponsiveness was rapidly induced. In the thymus, in situ apoptosis in the cortex and at the corticomedullary junction was responsible for a synchronous and massive deletion of CD4~+ CD8~+ thymocytes.

机译：通过使用转基因小鼠对包含流感病毒血凝素（HA）肽（包含氨基酸126-138）具有特异性的T细胞受体，已经分析了通过全身性施用高剂量的水性抗原来诱导耐受的机制。静脉注射750（但不是75）μgHA肽后，迅速诱发低反应状态。在胸腺中，皮质和皮质髓质交界处的原位凋亡是CD4〜+ CD8〜+胸腺细胞同步大量缺失的原因。

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第7期|p.3031-3036|共6页
作者
Roland S. Liblau; Roland Tisch; Kevan Shokat;
展开▼
作者单位

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词

相似文献

外文文献
中文文献
专利

1. Mechanisms of acquired thymic tolerance in vivo: intrathymic injection of antigen induces apoptosis of thymocytes and peripheral T cell anergy. [J] . Chen W, Sayegh MH, Khoury SJ The Journal of Immunology: Official Journal of the American Association of Immunologists . 1998,第3期

机译：体内获得胸腺耐受的机制：胸腺内注射抗原诱导胸腺细胞凋亡和外周T细胞无反应性。
2. Mechanisms of Acquired Thymic Tolerance In Vivo: Intrathymic Injection of Antigen Induces Apoptosis of Thymocytes and Peripheral T Cell Anergy [J] . Wanjun Chen, Mohamed H. Sayegh, Samia J. Khoury The journal of immunology . 1998,第3期

机译：体内获得的胸腺耐受性的机制：胸腺内注射抗原诱导胸腺细胞凋亡和外周T细胞无能。
3. A possible role of endogenous central corticotrophin releasing factor in lipopolysaccharide induced thymic involution and cell apoptosis: Effect of peripheral injection of corticotrophin releasing factor [J] . Ullewar Meenal P., Umathe Sudhir N. Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2015,第Null期

机译：内源性促肾上腺皮质激素释放因子在脂多糖诱导的胸腺复性和细胞凋亡中的可能作用：外周注射促肾上腺皮质激素释放因子的作用
4. α-Al_2O_3 Nanowire Delivery of Soluble Antigen for Cross- Priming of Cytotoxic T-cells [C] . Rebecca Schaller, Haiyan Li, Micah Eastman, Microscopy and microanalysis.;Microscopy and microanalysis. . 2010

机译：可溶性抗原的α-Al_2O_3纳米线递送，可用于细胞毒性T细胞的交叉启动
5. Increased density of class I major histocompatibility complex antigens and decreased density of T-cell differentiation antigens in the early stages of T-cell activation [D] . 松井良樹 1988

机译：在T细胞活化的早期，I类主要组织相容性复合抗原的密度增加，而T细胞分化抗原的密度降低
6. Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis. [O] . R S Liblau, R Tisch, K Shokat, 1996

机译：静脉注射可溶性抗原诱导胸腺和外周T细胞凋亡。
7. Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis. [O] . Liblau, R S, Tisch, R, Shokat, K, 1996

机译：静脉注射可溶性抗原诱导胸腺和外周T细胞凋亡。

Intravenous injection of soluble antigen induces thymic and peripheral T-cell apoptosis

摘要

著录项

相似文献

相关主题

期刊订阅