• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Psychopharmacology Bulletin >Combined Antipsychotics and Electroconvulsive Therapy in an Acutely Psychotic Patient with Treatment-resistant Schizophrenia
【2h】

Combined Antipsychotics and Electroconvulsive Therapy in an Acutely Psychotic Patient with Treatment-resistant Schizophrenia

机译：抗精神分裂症急性精神病患者联合抗精神病药物和电抽搐疗法

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Treatment of patients with Treatment-resistant Schizophrenia (TRS), who fail to respond to multiple antipsychotic trials, including clozapine (CLZ), is challenging. Several alternative strategies are reported in studies, one of which includes augmenting antipsychotics (AP) with Electroconvulsive therapy (ECT). We discuss a case of an acutely psychotic patient with TRS who responded effectively and sustained remission to this strategy which was ECT combined with two AP, CLZ and aripiprazole. Notable improvement in clinical and cognitive outcomes was seen with just five right unilateral ECT sessions, CLZ titrated up to 62.5 mg/d and aripiprazole 20 mg/d with no adverse effects. Nine days into the psychiatric hospitalization, patient had decreased total scores on the Positive and Negative Syndrome Scale by 44% and an improved score on the St. Louis University Mental Status Exam by increasing from 3 to 22. This case report suggests that a subgroup of patients with TRS could benefit from a trial of adjunct ECT combined with AP to achieve a rapid alleviation of positive and negative symptoms which allows patients to have greater functional stability.
机译：对包括氯氮平（CLZ）在内的多种抗精神病药物试验均无反应的耐药性精神分裂症（TRS）患者的治疗具有挑战性。研究中报告了几种替代策略，其中一种策略包括通过电惊厥疗法（ECT）增强抗精神病药（AP）。我们讨论了一个患有TRS的急性精神病患者，该患者有效反应并持续缓解了该策略，该策略是ECT结合两个AP，CLZ和阿立哌唑。仅进行了5次正确的单侧ECT疗程，临床和认知结果均得到显着改善，CLZ滴定至62.5 mg / d，阿立哌唑20 mg / d，无不良反应。进入精神科住院的9天，患者的阳性和阴性综合征量表总分降低了44％，而圣路易斯大学心理状况测验的总分从3提高到22。该病例报告表明， TRS患者可从ECT联合AP的辅助试验中受益，以快速缓解阳性和阴性症状，从而使患者具有更大的功能稳定性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号