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首页> 美国卫生研究院文献>The Scientific World Journal >Hypertonic Saline in Treatment of Pulmonary Disease in Cystic Fibrosis
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Hypertonic Saline in Treatment of Pulmonary Disease in Cystic Fibrosis

机译：高渗盐水治疗囊性纤维化肺病

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The pathogenesis of lung disease in cystic fibrosis is characterised by decreased airway surface liquid volume and subsequent failure of normal mucociliary clearance. Mucus within the cystic fibrosis airways is enriched in negatively charged matrices composed of DNA released from colonizing bacteria or inflammatory cells, as well as F-actin and elevated concentrations of anionic glycosaminoglycans. Therapies acting against airway mucus in cystic fibrosis include aerosolized hypertonic saline. It has been shown that hypertonic saline possesses mucolytic properties and aids mucociliary clearance by restoring the liquid layer lining the airways. However, recent clinical and bench-top studies are beginning to broaden our view on the beneficial effects of hypertonic saline, which now extend to include anti-infective as well as anti-inflammatory properties. This review aims to discuss the described therapeutic benefits of hypertonic saline and specifically to identify novel models of hypertonic saline action independent of airway hydration.
机译：囊性纤维化中肺部疾病的发病机制的特征是气道表面液量减少以及随后的正常粘膜纤毛清除功能丧失。囊性纤维化气道内的粘液富含带负电荷的基质，该基质由定植细菌或炎性细胞释放的DNA以及F-肌动蛋白和高浓度的阴离子糖胺聚糖组成。在囊性纤维化中针对气道粘液起作用的疗法包括雾化高渗盐水。已经表明，高渗盐水具有粘液溶解特性，并且通过恢复气道内的液体层而有助于粘膜纤毛清除。然而，最近的临床和台式研究开始扩大我们对高渗盐水的有益作用的见解，高渗盐水现已扩展到包括抗感染和抗炎特性。这篇综述的目的是讨论所描述的高渗盐水的治疗益处，并且特别是要确定与气道水合作用无关的高渗盐水作用的新型模型。

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