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Alum Catalyzed Simple Efficient and Green Synthesis of 2-3-Amino-5-methyl-5-(pyridin-3-yl)-15-dihydro-4H-124-triazol-4-ylpropanoic Acid Derivatives in Aqueous Media

机译：明矾催化2- 3-氨基-5-甲基-5-（吡啶-3-基）-15-二氢-4H-124-三唑-4-基的简单有效和绿色合成介质中的丙酸衍生物

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Alum (KAl(SO4)2 ·12H2O) is an inexpensive, efficient, and nontoxic catalyst used for the synthesis of 2-[3-amino-5-methyl-5-(pyridin-3-yl)-1,5-dihydro-4H-1,2,4-triazol-4-yl]propanoic acid derivatives in aqueous media by the reaction of 3-acetyl pyridine >(1), amino acids >(2)/>(6), and thiosemicarbazide >(4) at 80°C. This methodology offers significant improvements for the synthesis of products with regards to the yield of products, simplicity in operation, and green aspects by avoiding toxic catalysts which uphold the motto of green chemistry. Synthesized compounds have been characterized by FT-IR, ¹³C NMR, and ¹HNMR spectroscopy.

机译：明矾（KAl（SO4）2·12H2O）是一种廉价，高效且无毒的催化剂，用于合成2- [3-氨基-5-甲基-5-（吡啶-3-基）-1,5-二氢3-乙酰吡啶>（1），氨基酸>（2）的反应在水介质中产生-4H-1,2,4-三唑-4-基]丙酸衍生物在80°C时为strong> / >（6）和硫代氨基脲>（4）。该方法通过避免有毒催化剂而坚持绿色化学的座右铭，从而在产物的产率，操作简便性和绿色方面方面为产物的合成提供了显着的改进。通过FT-IR，^{13 C NMR和^{1 HNMR光谱对合成的化合物进行了表征。}}

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期刊名称 The Scientific World Journal
作者
Harshita Sachdeva; Diksha Dwivedi; Rekha Saroj;
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年(卷),期 2013(2013),-1
年度 2013
页码 716389
总页数 7
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1. Alum Catalyzed Simple, Efficient, and Green Synthesis of 2-[3-Amino-5-methyl-5-(pyridin-3-yl)-1,5-dihydro-4H-1,2,4-triazol-4-yl]propanoic Acid Derivatives in Aqueous Media [J] . HarshitaSachdeva, DikshaDwivedi, RekhaSaroj ScientificWorldJournal . 2013,第3期

机译：催化简单，高效，绿色合成的2- [3-氨基-5-甲基-5-（吡啶-3-基）-1,5-二氢-4H-1,2,4-Tri唑-4- y1 ]水性介质中的丙酸衍生物
2. Alum catalyzed simple and efficient synthesis of 5-arylidene-2,4-thiazolidinedione in aqueous media [J] . Shelke K.F., Sapkal S.B., Kakade G.K., Green Chemistry Letters and Reviews . 2010,第1a4期

机译：明矾在水性介质中催化简单有效地合成5-亚芳基-2,4-噻唑烷二酮
3. Alum catalyzed simple and efficient synthesis of 5-arylidene-2,4-thiazolidinedione in aqueous media [J] . Kiran F. Shelkea Suryakant B. Sapkala Gopal K. Kakadea Sandip A. Sadaphala Bapurao B. Shingatea Murlidhar S. Shingarea* Green Chemistry Letters and Reviews . 2010,第1期

机译：明矾在水性介质中催化简单有效地合成5-亚芳基-2,4-噻唑烷二酮
4. Catalytic Asymmetric Synthesis of α-Amino Acid Derivatives: Approaches toward Green Sustainable Methodology for Preparation of Optically Active Amino Acids [C] . Yasuhiro Yamashita, Shu Kobayashi Asymmetric synthesis and application of α-amino acids . 2007

机译：催化不对称合成α-氨基酸衍生物：绿色可持续方法制备光学活性氨基酸的方法
5. New developments toward the synthesis of heterocycles and applications in green chemistry. I. A simple and essentially one-pot synthesis of N-aminated heterocycles using phase transfer catalyst (Aliquat-336). II. Synthesis of pharmaceutically important pyrrole derivatives. III. Applications in green chemistry: Surfactant-mediated environmentally friendly cleavage of aromatic esters and trans-esterification under solvent-free neutral conditions . [D] . Patel, Nitinchandra. 2005

机译：杂环合成的新进展及其在绿色化学中的应用。 I.使用相转移催化剂（Aliquat-336）简单且基本上一锅合成N-胺化的杂环。二。药学上重要的吡咯衍生物的合成。三，在绿色化学中的应用：在无溶剂的中性条件下，表面活性剂介导的环境友好的芳族酯裂解和酯交换反应。
6. A facile and efficient synthesis of 18-dioxodecahydroacridines derivatives catalyzed by cobalt–alanine metal complex under aqueous ethanol media [O] . M. Mujahid Alam, Ahmed T. Mubarak, Mohammed A. Assiri, 2019

机译：乙醇水溶液中钴-丙氨酸金属配合物催化简便高效合成18-二氧杂十二烷基hydro啶衍生物
7. Greener, Simple and Efficient Synthesis of Some Oxazine-2-amine Derivatives by Preheated Fly-Ash Catalyzed Cyclization of Aryl Chalcones under Solvent-Free Conditions [O] . G. Thirunarayanan 2014

机译：在无溶剂条件下通过预热的粉煤灰预热的粉煤灰催化环化进行格林，简单，高效地合成一些恶唑催化环化

Alum Catalyzed Simple Efficient and Green Synthesis of 2-3-Amino-5-methyl-5-(pyridin-3-yl)-15-dihydro-4H-124-triazol-4-ylpropanoic Acid Derivatives in Aqueous Media

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