Controlled drug delivery vehicles for cancer treatment and their performance

机译：用于癌症治疗的受控药物输送工具及其性能

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Although conventional chemotherapy has been successful to some extent, the main drawbacks of chemotherapy are its poor bioavailability, high-dose requirements, adverse side effects, low therapeutic indices, development of multiple drug resistance, and non-specific targeting. The main aim in the development of drug delivery vehicles is to successfully address these delivery-related problems and carry drugs to the desired sites of therapeutic action while reducing adverse side effects. In this review, we will discuss the different types of materials used as delivery vehicles for chemotherapeutic agents and their structural characteristics that improve the therapeutic efficacy of their drugs and will describe recent scientific advances in the area of chemotherapy, emphasizing challenges in cancer treatments.

机译：尽管常规化学疗法在某种程度上已经成功，但是化学疗法的主要缺点是其生物利用度差，高剂量需求，不良副作用，低治疗指数，多种耐药性的形成以及非特异性靶向。药物输送载体的开发的主要目的是成功解决这些与输送有关的问题，并将药物携带到所需的治疗作用部位，同时减少不良副作用。在这篇综述中，我们将讨论用作化学治疗剂递送工具的不同类型的材料及其结构特征，这些材料可改善其药物的治疗功效，并描述化学疗法领域的最新科学进展，强调癌症治疗中的挑战。

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期刊名称 Signal Transduction and Targeted Therapy
作者
Sudipta Senapati; Arun Kumar Mahanta; Sunil Kumar; Pralay Maiti;
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年(卷),期 2018(3),-1
年度 2018
页码 7
总页数 19
原文格式 PDF
正文语种
中图分类生理学;
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专利

1. Controlled drug delivery vehicles for cancer treatment and their performance [J] . Sudipta Senapati, Arun Kumar Mahanta, Sunil Kumar, Signal transduction and targeted therapy. . 2018,第1期

机译：用于癌症治疗的受控药物输送工具及其性能
2. Melt-extruded polyethylene oxide (PEO) rods as drug delivery vehicles: Formulation, performance as controlled release devices and the influence of co-extruded excipients on drug release profiles [J] . Michael R. Mucalo, Michael J. Rathbone Chemistry in New Zealand . 2012,第3期

机译：熔融挤出的聚环氧乙烷（PEO）棒作为药物输送工具：配方，控释装置的性能以及共挤出赋形剂对药物释放曲线的影响
3. Biodegradable poly(epsilon-caprolactone) as a controlled drug delivery vehicle of vancomycin for the treatment of MRSA infection [J] . Rai Alok, Senapati Sudipta, Saraf Shyam K., Journal of Materials Chemistry, B. materials for biology and medicine . 2016,第30期

机译：可生物降解的聚（ε-己内酯）作为万古霉素的受控药物输送载体，用于治疗MRSA感染
4. State Dependent Riccati Equation controlled drug delivery for mixed therapy of cancer treatment [C] . Naser Babaei, Metin U. Salamci, Tayfun Cimen IFAC Workshop on Control Applications of Optimization . 2016

机译：癌症治疗混合治疗的状态依赖性Riccati等式控制药物递送
5. Synthesis of a drug delivery vehicle for cancer treatment utilizing DNA-functionalized gold nanoparticles. [D] . Brann, Tyler. 2014

机译：利用DNA功能化的金纳米粒子合成用于癌症治疗的药物递送载体。
6. Alginate-based hydrogels as drug delivery vehicles in cancer treatment and their applications in wound dressing and 3D bioprinting [O] . Farhad Abasalizadeh, Sevil Vaghefi Moghaddam, Effat Alizadeh, 2020

机译：基于藻酸盐的水凝胶在癌症治疗中作为药物递送载体及其在伤口包扎和3D生物打印中的应用
7. Controlled drug delivery vehicles for cancer treatment and their performance [O] . Sudipta Senapati, Arun Kumar Mahanta, Sunil Kumar, 2018

机译：受控药物递送型癌症治疗及其性能

Controlled drug delivery vehicles for cancer treatment and their performance

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