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Neural correlates of masked and unmasked face emotion processing in youth with severe mood dysregulation

机译:严重情绪失调的年轻人中掩盖和未掩盖面部情绪处理的神经相关性

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摘要

Reproducibility of results is important in improving the robustness of conclusions drawn from research, particularly in functional magnetic resonance imaging (fMRI). In this study, we aim to replicate a previous study on the neural correlates of face emotion processing above and below awareness level using an independent sample of youth with severe mood dysregulation (SMD) and healthy volunteers (HV). We collected fMRI data in 17 SMD and 20 HV, using an affective priming paradigm with masked (17 ms) and unmasked (187 ms) faces (angry, happy, neutral, blank oval). When processing masked and unmasked angry faces, SMD patients exhibited increased activation in the parahippocampal gyrus (PHG) and superior temporal gyrus relative to HV. When processing masked and unmasked happy faces, SMD patients showed decreased activation in the insula, PHG and thalamus compared with HV. During masked face processing in general across emotions, youth with SMD showed greater ventromedial prefrontal cortex (vmPFC) activation relative to HV. Perturbed activation in emotion processing areas (e.g. insula, PHG, superior temporal gyrus and thalamus) manifests as hyper-sensitivity toward negative emotions and hypo-sensitivity toward positive emotions may be important in the etiology and maintenance of irritability, aggression and depressive symptoms in SMD. vmPFC dysfunction may mediate over-reactivity to face emotions associated with irritability.
机译:结果的可重复性对于提高从研究得出的结论的鲁棒性非常重要,特别是在功能磁共振成像(fMRI)中。在这项研究中,我们的目标是使用独立的严重情绪失调的年轻人(SMD)和健康志愿者(HV)的独立样本,来复制关于认知水平以上和以下的面部情绪处理的神经相关性的先前研究。我们使用17毫秒和17毫秒无脸(生气,高兴,中立,空白椭圆形)的情感启动范例收集了17个SMD和20 HV的fMRI数据。当处理蒙面和未蒙面的愤怒面孔时,相对于HV,SMD患者在海马旁回(PHG)和颞上回的激活增加。与HV相比,当处理带有遮罩和未遮罩的笑脸时,SMD患者的岛顶,PHG和丘脑激活降低。在一般跨情绪的蒙面处理过程中,相对于HV,SMD青年表现出更大的腹侧前额叶皮层(vmPFC)激活。情绪处理区域(例如,岛,PHG,颞上回和丘脑)的扰动激活表现为对负面情绪的超敏反应和对正面情绪的低敏性可能在SMD的病因学和维持易怒,攻击性和抑郁症状中很重要。 vmPFC功能障碍可能会介导过度反应,以面对与烦躁相关的情绪。

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