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首页> 美国卫生研究院文献>Journal of Visualized Experiments : JoVE >A Facile and Eco-friendly Route to Fabricate Poly(Lactic Acid) Scaffolds with Graded Pore Size
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A Facile and Eco-friendly Route to Fabricate Poly(Lactic Acid) Scaffolds with Graded Pore Size

机译：一种方便且环保的方法来制造孔径分级的聚乳酸支架

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Over the recent years, functionally graded scaffolds (FGS) gaineda crucial role for manufacturing of devices for tissue engineering. The importance of this new field of biomaterials research is due to the necessity to develop implants capable of mimicking the complex functionality of the various tissues, including a continuous change from one structure or composition to another. In this latter context, one topic of main interest concerns the design of appropriate scaffolds for bone-cartilage interface tissue. In this study, three-layered scaffolds with graded pore size were achieved by melt mixing poly(lactic acid) (PLA), sodium chloride (NaCl) and polyethylene glycol (PEG). Pore size distributions were controlled by NaCl granulometry and PEG solvation. Scaffolds were characterized from a morphological and mechanical point of view. A correlation between the preparation method, the pore architecture and compressive mechanical behavior was found. The interface adhesion strength was quantitatively evaluated by using a custom-designed interfacial strength test. Furthermore, in order to imitate the human physiology, mechanical tests were also performed in phosphate buffered saline (PBS) solution at 37 °C. The method herein presented provides a high control of porosity, pore size distribution and mechanical performance, thus offering the possibility to fabricate three-layered scaffolds with tailored properties by following a simple and eco-friendly route.
机译：近年来，功能梯度支架（FGS）在组织工程设备的制造中起着至关重要的作用。这个新的生物材料研究领域的重要性是由于必须开发能够模仿各种组织的复杂功能的植入物，包括从一种结构或组成到另一种的连续变化。在后一种情况下，一个主要关注的话题涉及用于骨-软骨界面组织的适当支架的设计。在这项研究中，通过熔融混合聚乳酸（PLA），氯化钠（NaCl）和聚乙二醇（PEG）来实现具有分级孔径的三层支架。孔尺寸分布通过NaCl粒度测定法和PEG溶剂化来控制。从形态和力学的角度对脚手架进行了表征。发现制备方法，孔结构和压缩力学行为之间存在相关性。通过使用定制设计的界面强度测试定量评估了界面粘合强度。此外，为了模仿人体生理，还在37°C的磷酸盐缓冲盐水（PBS）溶液中进行了机械测试。本文提出的方法提供了对孔隙率，孔径分布和机械性能的高度控制，从而提供了通过遵循简单且生态友好的途径来制造具有定制性质的三层支架的可能性。

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