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首页> 美国卫生研究院文献>Toxins >Accumulation and Elimination Dynamics of the Hydroxybenzoate Saxitoxin Analogues in Mussels Mytilus galloprovincialis Exposed to the Toxic Marine Dinoflagellate Gymnodinium catenatum
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Accumulation and Elimination Dynamics of the Hydroxybenzoate Saxitoxin Analogues in Mussels Mytilus galloprovincialis Exposed to the Toxic Marine Dinoflagellate Gymnodinium catenatum

机译：暴露于有毒海洋鞭毛藻鞭毛的贻贝贻贝中羟基苯甲酸盐毒素毒素类似物的积累和消除动力学

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摘要

Paralytic shellfish poisoning (PSP) is a severe food-borne illness, caused by the ingestion of seafood containing paralytic shellfish toxins (PST), which are naturally produced by marine dinoflagellates and accumulate in shellfish during algae blooms. Novel PST, designated as hydroxybenzoate analogues (also known as GC toxins), was relatively recently discovered in Gymnodinium catenatum strains worldwide. However, to date, there have been no studies examining their accumulation in shellfish. In this study, mussels (Mytilus galloprovincialis) were exposed to G. catenatum for five days and then exposed to a non-toxic diet for 24 h, to investigate the toxin’s accumulation/elimination dynamics. As determined by UHPLC-HILIC-MS/MS, the hydroxybenzoate analogues, GC1 to GC6, comprised 41% of the algae toxin profile and only 9% in mussels. Elimination of GC toxins after 24 h was not evident. This study highlights that a relevant fraction of PST in mussels are not routinely analysed in monitoring programs and that there is a need to better understand the toxicological potential of the hydroxybenzoate analogues, in order to properly address the risk of G. catenatum blooms.
机译：麻痹性贝类中毒（PSP）是一种严重的食源性疾病，是由于摄入含有麻痹性贝类毒素（PST）的海产品引起的，海产品中的鞭毛藻自然产生这种毒素，并在藻类开花期间在贝类中积聚。相对较新的PST，被称为羟基苯甲酸酯类似物（也称为GC毒素），是最近在全世界的Gymnodinium catenatum菌株中发现的。然而，迄今为止，还没有研究检查它们在贝类中的积累。在这项研究中，贻贝（Mytilus galloprovincialis）暴露于链霉菌5天，然后暴露于无毒饮食24 h，以研究毒素的蓄积/消除动态。通过UHPLC-HILIC-MS / MS测定，羟基苯甲酸酯类似物GC1至GC6占藻毒素谱的41％，而贻贝仅占9％。 24小时后消除GC毒素并不明显。这项研究强调，在监视程序中不会常规分析贻贝中PST的相关部分，因此有必要更好地了解羟基苯甲酸酯类似物的毒理学潜力，以便正确解决链状芽孢杆菌开花的风险。

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