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A genome-wide association meta-analysis of prognostic outcomes following cognitive behavioural therapy in individuals with anxiety and depressive disorders

机译：焦虑和抑郁症患者认知行为治疗后预后结果的全基因组关联荟萃分析

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Major depressive disorder and the anxiety disorders are highly prevalent, disabling and moderately heritable. Depression and anxiety are also highly comorbid and have a strong genetic correlation (rg ≈ 1). Cognitive behavioural therapy is a leading evidence-based treatment but has variable outcomes. Currently, there are no strong predictors of outcome. Therapygenetics research aims to identify genetic predictors of prognosis following therapy. We performed genome-wide association meta-analyses of symptoms following cognitive behavioural therapy in adults with anxiety disorders (n = 972), adults with major depressive disorder (n = 832) and children with anxiety disorders (n = 920; meta-analysis n = 2724). We estimated the variance in therapy outcomes that could be explained by common genetic variants (h2SNP) and polygenic scoring was used to examine genetic associations between therapy outcomes and psychopathology, personality and learning. No single nucleotide polymorphisms were strongly associated with treatment outcomes. No significant estimate of h2SNP could be obtained, suggesting the heritability of therapy outcome is smaller than our analysis was powered to detect. Polygenic scoring failed to detect genetic overlap between therapy outcome and psychopathology, personality or learning. This study is the largest therapygenetics study to date. Results are consistent with previous, similarly powered genome-wide association studies of complex traits.
机译：严重的抑郁症和焦虑症非常普遍，致残且可遗传。抑郁和焦虑症也很常见，并且具有很强的遗传相关性（rg≈1）。认知行为疗法是一种领先的循证疗法，但结局可变。当前，尚无强有力的预后指标。治疗遗传学研究旨在确定治疗后预后的遗传预测因子。在认知行为治疗后，我们对焦虑障碍的成年人（n = 972），成人抑郁症的成年人（n = 832）和焦虑症的孩子（n = 920）进行了全基因组症状关联荟萃分析。 = 2724）。我们估计了治疗结果的差异，可以用常见的遗传变异（h 2 SNP）进行解释，并使用多基因评分来检查治疗结果与心理病理，人格和学习之间的遗传关联。没有单核苷酸多态性与治疗结果密切相关。无法获得h 2 SNP的显着估计，表明治疗结果的遗传力小于我们的分析能力。多基因评分未能检测出治疗结果与心理病理，人格或学习之间的遗传重叠。这项研究是迄今为止最大的治疗遗传学研究。结果与先前对复杂性状的全基因组关联研究相似。

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