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首页> 美国卫生研究院文献>World Journal of Gastroenterology >Expression of p53 and C-myc genes and its clinical relevance in the hepatocellular carcinomatous and pericarcinomatous tissues
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Expression of p53 and C-myc genes and its clinical relevance in the hepatocellular carcinomatous and pericarcinomatous tissues

机译：p53和C-myc基因在肝癌及癌旁组织中的表达及其临床意义

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AIM: To investigate the possible roles of p53 and C-myc genes in the primary hepatocellular carcinogenesis and the relationship between the liver hyperplastic nodule (LHN) and hepatocellular carcinoma (HCC).METHODS: The expression of p53 and C-myc genes was detected immunohist-ochemically in 73 and 60 cases of HCC and pericarcinomatous tissues, respectively.RESULTS: The positive expression of p53 in HCC was significantly higher than that in pericarcinomatous tissues (P < 0.05). In pericarcinomatous tissues, the p53 expression was observed only in LHN, but not in liver cirrhosis (LC) and normal liver tissues. The positive expression rate of C-myc in HCC or LHN was significantly higher than that in LC or normal liver tissues (P < 0.05 and P < 0.01), however, no significant difference was found between HCC and LHN (P > 0.05). The positive expression rate of p53 and C-myc in HCC was correlated with the histological differentiation, that in the poorly differentiated was significantly higher than that in well differentiated samples (P < 0.05).CONCLUSION: The overexpression of p53 and C-myc genes might play a role in the carcinogenesis of HCC; And LHN seems a preneoplastic lesion related to hepatocarcinogenesis; No evidence supports that LC contribute directly to the hepatocarcinogenesis.
机译：目的：探讨p53和C-myc基因在原发性肝癌发生中的可能作用以及肝增生性结节（LHN）与肝细胞癌（HCC）之间的关系。方法：检测p53和C-myc基因的表达结果：分别在73例和60例肝癌和癌旁组织中进行免疫组化分析。结果：p53在肝癌组织中的阳性表达明显高于癌旁组织（P <0.05）。在癌旁组织中，仅在LHN中观察到p53表达，而在肝硬化（LC）和正常肝组织中未观察到。 HCC或LHN中C-myc的阳性表达率显着高于LC或正常肝组织（P <0.05和P <0.01），但在HCC和LHN之间无显着差异（P> 0.05）。结论：肝癌组织中p53和C-myc的阳性表达率与组织学分化程度相关，低分化组织中p53和C-myc的阳性表达率显着高于高分化样品（P <0.05）。可能在肝癌的癌变中起作用； LHN似乎是与肝癌发生有关的肿瘤前病变。没有证据支持LC直接促进肝癌的发生。

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