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首页> 美国卫生研究院文献>Journal of Veterinary Science >Improved rat spinal cord injury model using spinal cord compression by percutaneous method
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Improved rat spinal cord injury model using spinal cord compression by percutaneous method

机译：经皮方法加压脊髓改善大鼠脊髓损伤模型

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Here, percutaneous spinal cord injury (SCI) methods using a balloon catheter in adult rats are described. A balloon catheter was inserted into the epidural space through the lumbosacral junction and then inflated between T9-T10 for 10min under fluoroscopic guidance. Animals were divided into three groups with respect to inflation volume: 20 µL (n = 18), 50 µL (n = 18) and control (Fogarty catheter inserted but not inflated; n = 10). Neurological assessments were then made based on BBB score, magnetic resonance imaging and histopathology. Both inflation volumes produced complete paralysis. Gradual recovery of motor function occurred when 20 µL was used, but not after 50 µL was applied. In the 50 µL group, all gray and white matter was lost from the center of the lesion. In addition, supramaximal damage was noted, which likely prevented spontaneous recovery. This percutaneous spinal cord compression injury model is simple, rapid with high reproducibility and the potential to serve as a useful tool for investigation of pathophysiology and possible protective treatments of SCI in vivo.
机译：在此，描述了在成年大鼠中使用球囊导管的经皮脊髓损伤（SCI）方法。将球囊导管通过腰s连接处插入硬膜外腔，然后在荧光镜引导下在T9-T10之间充气10分钟。就充气量而言，将动物分为三组：20 µL（n = 18），50 µL（n = 18）和对照组（已插入香烟导管但未充气； n = 10）。然后基于BBB评分，磁共振成像和组织病理学进行神经学评估。两种通货膨胀量都使瘫痪。当使用20 µL时，运动功能逐渐恢复，但使用50 µL后，运动功能没有逐渐恢复。在50 µL组中，所有灰色和白色物质从病变中心消失。另外，注意到最大的损伤，这可能阻止了自发的恢复。这种经皮脊髓压迫性损伤模型简单，快速，可重现性高，并且有可能用作研究病理生理学和体内SCI可能的保护性治疗的有用工具。

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