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Assessment of biochemical markers in the early post-burn period for predicting acute kidney injury and mortality in patients with major burn injury: comparison of serum creatinine serum cystatin-C plasma and urine neutrophil gelatinase-associated lipocalin

机译:评估烧伤后早期的生化指标以预测严重烧伤患者的急性肾损伤和死亡率:血清肌酐血清胱抑素-C血浆和尿中性粒细胞明胶酶相关脂蛋白的比较

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摘要

IntroductionThe reported mortality rates range from 28% to 100% in burn patients who develop acute kidney injury (AKI) and from 50% to 100% among such patients treated with renal replacement therapy. Recently, the serum cystatin C and plasma and urine neutrophil gelatinase-associated lipocalin (NGAL) levels have been introduced as early biomarkers for AKI; the levels of these biomarkers are known to increase 24 to 48 hours before the serum creatinine levels increase. In this study, we aimed to estimate the diagnostic utility of the cystatin C and plasma and urine NGAL levels in the early post-burn period as biomarkers for predicting AKI and mortality in patients with major burn injuries.
机译:前言据报道,在发生急性肾损伤(AKI)的烧伤患者中,死亡率为28%至100%,而在接受肾脏替代疗法治疗的此类患者中,死亡率为50%至100%。最近,血清半胱氨酸蛋白酶抑制剂C和血浆及尿中性粒细胞明胶酶相关的脂钙素(NGAL)的水平已被引入作为AKI的早期生物标志物。已知这些生物标志物的水平会在血清肌酐水平升高之前的24至48小时内升高。在这项研究中,我们旨在评估烧伤后早期胱抑素C和血浆及尿液NGAL水平的诊断效用,作为预测严重烧伤患者AKI和死亡率的生物标志物。

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