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首页> 美国卫生研究院文献>Comparative Medicine >Development of Breeding Populations of Rhesus Macaques (Macaca mulatta) That Are Specific Pathogen-free for Rhesus Cytomegalovirus
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Development of Breeding Populations of Rhesus Macaques (Macaca mulatta) That Are Specific Pathogen-free for Rhesus Cytomegalovirus

机译：恒河猴巨巨病毒无病原的恒河猕猴（Macaca mulatta）繁殖种群的发展

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Development of breeding colonies of rhesus macaques (Macaca mulatta) that are specific pathogen-free (SPF) for rhesus cytomegalovirus (RhCMV) is relatively straightforward and requires few modifications from current SPF programs. Infants separated from the dam at or within a few days of birth and cohoused with similarly treated animals remain RhCMV seronegative indefinitely, provided they are never directly or indirectly exposed to a RhCMV-infected monkey. By systematically cohousing seronegative animals into larger social cohorts, breeding populations of animals SPF for RhCMV can be established. The additional costs involved in expanding the current definition of SPF status to include RhCMV are incremental compared with the money already being spent on existing SPF efforts. Moreover, the large increase in research opportunities available for RhCMV-free animals arguably would far exceed the development costs. Potential new areas of research and further expansion of existing research efforts involving these newly defined SPF animals would have direct implications for improvements in human health.
机译：恒河猴巨细胞病毒（RhCMV）的无特定病原体（SPF）的恒河猴（Macaca mulatta）繁殖菌落的开发相对简单，需要从当前的SPF程序进行少量修改。从大坝中分离出来的婴儿在出生时或几天之内并与类似治疗的动物一起饲养在一起，可以无限期保持RhCMV血清阴性，前提是他们绝不直接或间接暴露于感染RhCMV的猴子。通过系统地将血清阴性的动物纳入较大的社会群体，可以建立RhCMV的SPF繁殖种群。与已经在现有SPF工作上花费的资金相比，将SPF身份的当前定义扩展到包括RhCMV所涉及的额外费用是递增的。而且，无RhCMV的动物的大量研究机会可以说远远超出了开发成本。潜在的新研究领域以及涉及这些新定义的SPF动物的现有研究工作的进一步扩展将对改善人类健康产生直接影响。

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