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首页> 美国卫生研究院文献>Case Reports in Gastroenterology >Efficacy of Combined Mesalazine Plus Corticosteroid Enemas for Diversion Colitis after Subtotal Colectomy for Ulcerative Colitis
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Efficacy of Combined Mesalazine Plus Corticosteroid Enemas for Diversion Colitis after Subtotal Colectomy for Ulcerative Colitis

机译：联合美沙拉嗪联合皮质类固醇灌肠治疗溃疡性结肠炎大肠切除术后转移性结肠炎的疗效

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Diversion colitis is a benign inflammatory process that occurs in any part of the large bowel excluded from the fecal stream by a diverting colostomy. While most of the patients with diversion colitis usually are asymptomatic, a minority has abdominal pain and rectal discharge of blood or mucus. A 65-year-old Japanese man was diagnosed as having diversion colitis with ulcerative colitis at 4 months after subtotal colectomy. Corticosteroid and mesalazine enemas were started nonsynchronously. A proctoscopy after 2 months showed no response. Prednisolone injections were started at 1.0 mg/kg daily, but the mucosal inflammation still failed to improve. A combined mesalazine 1 g plus prednisolone sodium phosphate 20 mg enema was started once daily. The rectal bleeding and endoscopic findings improved. Finally proctectomy and ileal pouch-anal anastomosis were successfully performed. A combined mesalazine plus corticosteroid enema may be effective in patients with diversion colitis associated with ulcerative colitis.
机译：转移性结肠炎是一种良性炎症过程，通过分流结肠造口术在大肠的任何部分（从粪便流中排除）中发生。虽然大多数转移性结肠炎患者通常无症状，但少数患者有腹痛和直肠血液或粘液排出。结肠大部切除术后4个月，一名65岁的日本男子被诊断患有溃疡性结肠炎和转移性结肠炎。皮质类固醇和美沙拉嗪灌肠是非同步开始的。 2个月后的直肠镜检查无反应。泼尼松龙的注射剂量为每天1.0 mg / kg，但粘膜炎症仍未能改善。每天一次开始合并使用1毫克美沙拉嗪加泼尼松龙磷酸钠20毫克灌肠剂。直肠出血和内窥镜检查结果有所改善。最后，成功进行了直肠切除术和回肠袋肛门吻合术。合并美沙拉嗪加皮质类固醇灌肠剂可用于合并溃疡性结肠炎的转移性结肠炎患者。

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