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首页> 美国卫生研究院文献>Case Reports in Dermatological Medicine >Piperacillin/Tazobactam as Cause of Acute Generalized Exanthematous Pustulosis
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Piperacillin/Tazobactam as Cause of Acute Generalized Exanthematous Pustulosis

机译：哌拉西林/他唑巴坦是急性全身性皮疹的病因

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Acute generalized exanthematous pustulosis (AGEP) is a rare cutaneous adverse reaction mainly attributed to antibiotics. It is characterized by numerous, nonfollicular, sterile pustules, arising on an exanthematous and edematous base. It is a serious adverse reaction accompanied by fever and leukocytosis. Piperacillin/tazobactam is indicated for the treatment of patients with moderate to severe infections. Herein is reported a case of AGEP caused by piperacillin/tazobactam. A 78-year-old woman with metastatic breast cancer was presented to the emergency department reporting fever and groin pain. The laboratory analysis and more specifically urine cultivation showed a urinary tract infection by E. coli with sensitivity to piperacillin/tazobactam. She had no known allergies. She was started on intravenous piperacillin/tazobactam; she improved clinically on the second day, but on the fourth day of intravenous therapy, she developed extensive pustular rash on the folds and anterior proximal thighs, accompanied by fever and neutrophilia. Piperacillin/tazobactam administration was interrupted and she was given prednisolone for ten days. The patient improved clinically and her laboratory tests returned to normal after two weeks. AGEP is an uncommon side effect of piperacillin/tazobactam treatment and there are few cases reported.
机译：急性全身性皮疹性脓疱病（AGEP）是一种罕见的皮肤不良反应，主要归因于抗生素。它的特征是在皮上和水肿的基部上产生许多非小孔的无菌脓疱。这是伴随发烧和白细胞增多的严重不良反应。哌拉西林/他唑巴坦用于治疗中度至重度感染的患者。本文报道了哌拉西林/他唑巴坦引起的AGEP病例。一名患有转移性乳腺癌的78岁妇女被送往急诊科，报告了发烧和腹股沟痛。实验室分析，尤其是尿液培养显示对大肠杆菌的尿路感染对哌拉西林/他唑巴坦敏感。她没有已知的过敏。她开始接受静脉注射哌拉西林/他唑巴坦治疗；在第二天，她的临床状况有所改善，但是在静脉内治疗的第四天，她在褶皱和大腿前部出现了广泛的脓疱疹，并伴有发烧和中性粒细胞增多。哌拉西林/他唑巴坦给药中断，给予泼尼松龙十天。病人的临床状况有所改善，两周后实验室检查恢复正常。 AGEP是哌拉西林/他唑巴坦治疗的罕见副作用，报道的病例很少。

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