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首页> 外文期刊>Case Reports in Dermatological Medicine >Piperacillin/Tazobactam as Cause of Acute Generalized Exanthematous Pustulosis
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Piperacillin/Tazobactam as Cause of Acute Generalized Exanthematous Pustulosis

机译：Piperacillin / Tazobactam作为急性普通的exantimeatous脓疱病的原因

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Acute generalized exanthematous pustulosis (AGEP) is a rare cutaneous adverse reaction mainly attributed to antibiotics. It is characterized by numerous, nonfollicular, sterile pustules, arising on an exanthematous and edematous base. It is a serious adverse reaction accompanied by fever and leukocytosis. Piperacillin/tazobactam is indicated for the treatment of patients with moderate to severe infections. Herein is reported a case of AGEP caused by piperacillin/tazobactam. A 78-year-old woman with metastatic breast cancer was presented to the emergency department reporting fever and groin pain. The laboratory analysis and more specifically urine cultivation showed a urinary tract infection by E. coli with sensitivity to piperacillin/tazobactam. She had no known allergies. She was started on intravenous piperacillin/tazobactam; she improved clinically on the second day, but on the fourth day of intravenous therapy, she developed extensive pustular rash on the folds and anterior proximal thighs, accompanied by fever and neutrophilia. Piperacillin/tazobactam administration was interrupted and she was given prednisolone for ten days. The patient improved clinically and her laboratory tests returned to normal after two weeks. AGEP is an uncommon side effect of piperacillin/tazobactam treatment and there are few cases reported.
机译：急性普通的exanthematous pustulosis（Agep）是一种罕见的皮肤不良反应，主要归因于抗生素。它的特征在于exantimeatous和水肺碱上产生的众多非胶卷性无菌脓疱。它是一种严重的不良反应，伴有发烧和白细胞增多症。表明哌啶蛋白/塔沙漠酰胺用于治疗中度至严重感染的患者。据报道，哌啶蛋白/塔沙漠酰胺引起的龄患者。提出了一个78岁的女性，伴有转移性乳腺癌的急诊肿瘤报告发烧和腹股沟疼痛。实验室分析和更具体的尿液栽培显示大肠杆菌的尿路感染，对哌啶/塔沙漠酰胺的敏感性。她没有众所周知的过敏。她始于静脉注射哌啶/ Tazobactam;她在临床上改善了第二天，但在静脉治疗的第四天，她在褶皱和前近大腿上产生了广泛的脓疱疹，伴有发烧和中性粒细胞。哌啶蛋白/塔扎布坦氨酰胺局中断，她被赋予泼尼松龙十天。患者在临床上改进，她的实验室测试两周后恢复到正常。 AGEP是一种罕见的哌啶/ Tazobactam治疗副作用，报告了很少的情况。

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