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首页> 美国卫生研究院文献>The Canadian Veterinary Journal >Anesthesia of wood bison with medetomidine-zolazepam/tiletamine and xylazine-zolazepam/tiletamine combinations.
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Anesthesia of wood bison with medetomidine-zolazepam/tiletamine and xylazine-zolazepam/tiletamine combinations.

机译：美托咪定-左拉西坦/左旋多巴胺和甲苯噻嗪-左拉西坦/左旋多巴胺组合麻醉木材野牛。

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This study was designed to evaluate 2 combinations for immobilization of bison. Seven wood bison received 1.5 mg/kg body weight (BW) of xylazine HCl + 1.5 mg/kg BW of zolazepam HCl and 1.5 mg/kg BW of tiletamine HCl on one occasion. The bison received 60 micrograms/kg BW of medetomidine HCl + 0.6 mg/kg BW of zolazepam HCl and 0.6 mg/kg BW of tiletamine HCL on another occasion. Xylazine was antagonized with 3 mg/kg BW of tolazoline HCl and medetomidine HCl was antagonized with 180 micrograms/kg (BW) of atipamezole HCl. Temporal characteristics of immobilization and physiological effects (acid-base status, thermoregulatory, cardiovascular, and respiratory effects) of the drug combinations were compared. Induction was significantly faster with xylazine HCl-zolazepam HCl/tiletamine HCl. Recovery following antagonist administration was significantly faster with medetomidine HCl-zolazepam HCl/tiletamine HCl. The average drug volumes required were 7.00 mL of xylazine HCl-zolazepam HCl/tiletamine HCL and 2.78 mL of medetomidine HCl-zolazepam HCl/tiletamine HCl. Hypoxemia, hypercarbia, and rumenal tympany were the major adverse effects with both drug combinations.
机译：这项研究旨在评估固定野牛的2种组合。七只野牛一次接受1.5 mg / kg体重（BW）的盐酸赛拉嗪+ 1.5 mg / kg体重的唑拉西坦HCl和1.5 mg / kg体重的瓦他敏HCl。在另一情况下，野牛接受60毫克/千克体重的美托咪定HCl + 0.6毫克/千克体重的唑拉西坦HCl和0.6毫克/千克体重的瓦他敏盐酸盐。甲苯噻唑与3 mg / kg体重的甲苯磺酸托拉唑啉拮抗，而美托咪定HCl与180毫克/ kg（BW）的盐酸阿替哌唑拮抗。比较了固定的时间特性和药物组合的生理效应（酸碱状态，温度调节，心血管和呼吸效应）。用盐酸赛拉嗪-盐酸唑拉西坦/盐酸替他敏的诱导明显更快。使用美托咪定HCl-左唑西am HCl /盐酸替他敏HCl后，拮抗剂给药后的恢复明显更快。所需的平均药物量为7.00 mL盐酸甲苯噻嗪-盐酸左拉西帕姆/盐酸替他敏和2.78 mL盐酸美托咪定盐酸-左唑西坦/盐酸维他命胺。低氧血症，高碳酸血症和瘤胃气喘是两种药物联合使用的主要不良反应。

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