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Activated gastric cancer-associated fibroblasts contribute to the malignant phenotype and 5-FU resistance via paracrine action in gastric cancer

机译：活化的胃癌相关成纤维细胞通过旁分泌作用促进胃癌的恶性表型和5-FU耐药

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BackgroundCancer-associated fibroblasts (CAFs) play important roles in tumor progression. However, the behaviors of activated CAFs in gastric cancer remain to be determined. The aim of the present study was to investigate the correlations between activated gastric CAFs and the prognosis of patients with gastric cancer, and to determine the effects of activated CAFs on the malignant phenotype and 5-fluorouracil resistance in this cancer.

机译：背景癌症相关的成纤维细胞（CAF）在肿瘤进展中起重要作用。然而，活化的CAF在胃癌中的行为仍有待确定。本研究的目的是调查活化的胃CAFs与胃癌患者预后之间的相关性，并确定活化的CAFs对这种癌症的恶性表型和5-氟尿嘧啶耐药性的影响。

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期刊名称 Cancer Cell International
作者
Yongchen Ma; Jing Zhu; Shanwen Chen; Tengyu Li; Ju Ma; Shihao Guo; Jianwen Hu; Taohua Yue; Junling Zhang; Pengyuan Wang; Xin Wang; Guowei Chen; Yucun Liu;
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作者单位

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年(卷),期 2018(18),-1
年度 2018
页码 104
总页数 12
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
Gastric cancer Cancer-associated fibroblasts Activation Epithelial–mesenchymal transition Drug resistance;

机译：胃癌;癌症相关的成纤维细胞;活化;上皮-间质转化;耐药性;

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专利

1. Activated gastric cancer-associated fibroblasts contribute to the malignant phenotype and 5-FU resistance via paracrine action in gastric cancer [J] . Yongchen Ma, Jing Zhu, Shanwen Chen, Cancer Cell International . 2018,第1期

机译：活化的胃癌相关成纤维细胞通过旁分泌作用促进胃癌的恶性表型和5-FU耐药
2. Low expression of SPARC in gastric cancer-associated fibroblasts leads to stemness transformation and 5-fluorouracil resistance in gastric cancer [J] . Yongchen Ma, Jing Zhu, Shanwen Chen, Cancer Cell International . 2019,第1期

机译：胃癌相关成纤维细胞中SPARC的低表达导致胃癌的干性转化和5-氟尿嘧啶耐药性
3. Activation of Transforming Growth Factor Beta 1 Signaling in Gastric Cancer-associated Fibroblasts Increases Their Motility, via Expression of Rhomboid 5 Homolog 2, and Ability to Induce Invasiveness of Gastric Cancer Cells [J] . Ishimoto Takatsugu, Miyake Keisuke, Nandi Tannistha, Gastroenterology . 2017,第1期

机译：在胃癌相关成纤维细胞中转化生长因子β1信号传导的激活增加了它们的运动，通过表达菱形5同源物2，以及诱导胃癌细胞侵袭的能力
4. Combined Administration of 5-FU with CDHP Exert Synergistic Antitumor Effect for 5-FU Resistant Gastric Cancer Cells [C] . E, Sasaki, K. Tominaga, International Gastric Cancer Congress . 2005

机译：5-FU的组合施用CDHP施加5-FU耐胃癌细胞的协同抗肿瘤效果
5. Expression of sushi domain containing two reflects the malignant potential of gastric cancer [D] . Umeda Shinichi, 梅田晋一 2019

机译：Sushi域包含两个区域的表达反映了胃癌的恶性潜能
6. Macrophages activate mesenchymal stem cells to acquire cancer-associated fibroblast-like features resulting in gastric epithelial cell lesions and malignant transformation in vitro [O] . Qiang Zhang, Shuo Chai, Wei Wang, -1

机译：巨噬细胞激活间充质干细胞以获取与癌症相关的成纤维细胞样特征导致胃上皮细胞病变和体外恶变
7. Activated gastric cancer-associated fibroblasts contribute to the malignant phenotype and 5-FU resistance via paracrine action in gastric cancer [O] . Yongchen Ma, Jing Zhu, Shanwen Chen, 2018

机译：活化的胃癌相关的成纤维细胞通过胃癌中的旁静脉作用有助于恶性表型和5-FU抗性

Activated gastric cancer-associated fibroblasts contribute to the malignant phenotype and 5-FU resistance via paracrine action in gastric cancer

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