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首页> 美国卫生研究院文献>The Journal of Physiology >Differential changes in insulin-like growth factors and their binding proteins following asphyxia in the preterm fetal sheep
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Differential changes in insulin-like growth factors and their binding proteins following asphyxia in the preterm fetal sheep

机译：早产胎羊窒息后胰岛素样生长因子及其结合蛋白的差异性变化

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class="enumerated" style="list-style-type:decimal">The purpose of this study was to examine the changes in circulating concentrations of insulin-like growth factor (IGF)-I, IGF-II, IGF-binding protein (IGFBP)−1, IGFBP–2 and insulin following asphyxia in utero.Fetal sheep at 90–93 days gestation underwent either sham occlusion (n = 7) or asphyxia (n = 6) induced by complete umbilical cord occlusion for 30 min. Fetal blood samples were taken before occlusion and 4, 6, 24, 48 and 72 h post-occlusion.During the early phase of recovery there was a substantial fall (80 %) in circulating plasma IGF-I concentrations by 6 h post-asphyxia (P < 0.001). This was associated with a rapid rise in IGFBP-1 (P < 0.001), but no change in IGF-II or IGFBP-2. Insulin was significantly reduced at 4 h (P < 0.001) and glucose slightly elevated (P < 0.05), but insulin values returned to baseline by 6 h. Between 24 and 72 h of recovery, IGF-I gradually increased, IGFBP-1 returned to control values, and there was an increase in IGFBP-2 after 24 h (P < 0.05) and in IGF-II by 72 h (P < 0.05) after asphyxia.These data demonstrate a differential effect of asphyxia on the IGF axis of the premature fetal sheep. A key finding was the large fall in circulating IGF-I, but not IGF-II, during the early phase of recovery. IGF-I bioavailability was, in part, regulated by IGFBP-1, but maximal changes in IGF-I and IGFBP-1 were independent of plasma insulin and glucose.The impact of this substantial change in circulating IGF-I on the fetus is unknown. It may facilitate metabolic requirements by promoting catabolism. Alternatively, as IGFs play a role in wound repair, the acute changes in IGF-I and IGFBP-1 may reflect transport of IGF-I from the circulatory pool to injured tissues to promote wound repair.
机译：class =“ enumerated” style =“ list-style-type：decimal”> <！-list-behavior =枚举前缀-word = mark-type = decimal max-label-size = 0-> 这项研究的目的是检查宫内窒息后胰岛素样生长因子（IGF）-I，IGF-II，IGF结合蛋白（IGFBP）-1，IGFBP-2和胰岛素的循环浓度变化。妊娠90-93天的胎羊经历了30分钟完全脐带闭塞的假闭塞（n = 7）或窒息（n = 6）。在闭塞前和闭塞后4、6、24、48和72小时采集胎儿血样。 在恢复的早期阶段，循环血浆IGF-I大量下降（80％）窒息后6 h的浓度（P <0.001）。这与IGFBP-1的快速升高有关（P <0.001），但IGF-II或IGFBP-2没有变化。胰岛素在4 h时显着降低（P <0.001），葡萄糖略微升高（P <0.05），但在6 h时胰岛素值恢复到基线。在恢复的24至72小时之间，IGF-I逐渐升高，IGFBP-1恢复至对照值，而24小时后IGFBP-2增加（P <0.05），而72小时后IGF-II增加（P <0.05）。 0.05）。 这些数据证明了窒息对早产胎羊的IGF轴有不同的影响。一个关键发现是在恢复的早期循环中的IGF-I大量下降，但IGF-II却没有下降。 IGF-I的生物利用度部分受IGFBP-1调节，但IGF-I和IGFBP-1的最大变化与血浆胰岛素和葡萄糖无关。 这种实质性变化对循环IGF的影响-我在胎儿上是未知的。它可以通过促进分解代谢来促进代谢需求。另外，由于IGF在伤口修复中起作用，因此IGF-I和IGFBP-1的急性变化可能反映了IGF-I从循环池向损伤组织的转运，从而促进伤口修复。

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