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首页> 外文期刊>Journal of the Society for Gynecologic Investigation >The effect of mild hypothermia on insulin-like growth factors after severe asphyxia in the preterm fetal sheep.
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The effect of mild hypothermia on insulin-like growth factors after severe asphyxia in the preterm fetal sheep.

机译：亚低温对早产胎羊严重窒息后胰岛素样生长因子的影响。

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OBJECTIVES: Persistent reductions in insulin-like growth factor I (IGF-I) levels in the preterm infant are strongly associated with increased risk of retinopathy and other complications, and may result from exposure to severe hypoxia. The effects of a potential new treatment for hypoxic-ischemic encephalopathy, cerebral hypothermia, on the responses of the IGF axis to hypoxia are unknown. The aim of this study was to examine the effects of prenatal asphyxia and cerebral hypothermia on changes in IGF-I and -II, IGF-binding protein 1 (IGFBP-1), and insulin levels. METHODS: Fetal sheep at 0.7 of gestation underwent either sham asphyxia and sham cooling (n = 7), asphyxia induced by 25 minutes of complete umbilical cord occlusion alone (n = 8), or asphyxia and head cooling (n = 8, extradural temperature 29.5 +/- 2.6C [vs 39.4 +/- 0.3C; P < .05]). Fetuses were studied for 3 days post-insult, during which time fetal blood samples were taken for endocrine measurements. RESULTS: There were no IGF axis changes during occlusion. Plasma IGF-I levels significantly decreased between 6 hours and 48 hours after asphyxia and IGF-II levels by 10 hours, in both asphyxia groups. IGFBP-1 rose from 4 hours, reaching a peak at 10 hours and returning to control values by 48 hours in the normothermia group, and by 24 hours in the hypothermia group. Insulin levels decreased between 2 hours and 10 hours after asphyxia in both asphyxia groups, and subsequently normalized. CONCLUSIONS: This study demonstrates for the first time that transient asphyxia in the preterm sheep fetus is associated with a significant decrease in IGF-II as well as IGF-I during recovery, and that these responses are not altered by mild systemic hypothermia.
机译：目的：早产儿胰岛素样生长因子I（IGF-I）水平的持续降低与视网膜病变和其他并发症的风险增加密切相关，并且可能是由于暴露于严重的缺氧导致的。缺氧缺血性脑病，脑低温的潜在新疗法对IGF轴对缺氧反应的影响尚不清楚。这项研究的目的是检查产前窒息和脑低温对IGF-I和-II，IGF结合蛋白1（IGFBP-1）和胰岛素水平变化的影响。方法：妊娠0.7的胎羊进行假窒息和假冷却（n = 7），仅通过完全脐带闭塞25分钟（n = 8）或窒息和头部冷却（n = 8，硬膜外温度）引起的窒息29.5 +/- 2.6C [vs 39.4 +/- 0.3C; P <.05]。在受伤后三天对胎儿进行研究，在此期间采集胎儿血样进行内分泌测量。结果：闭塞期间IGF轴没有改变。两组窒息后，血浆IGF-I水平在窒息后6小时至48小时之间显着降低，而IGF-II水平则在10小时后显着下降。 IGFBP-1从4小时开始上升，在10小时达到峰值，在正常体温组中48小时，在体温较低组中24小时恢复到对照值。两组窒息后，胰岛素水平在窒息后2小时至10小时之间下降，并随后恢复正常。结论：这项研究首次证明早产绵羊胎儿的短暂窒息与恢复期间IGF-II和IGF-I的显着降低有关，并且轻度的全身性低温不会改变这些反应。

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