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首页> 美国卫生研究院文献>British Journal of Cancer >Changes in hepatic haemodynamics in rats with overt liver tumour.
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Changes in hepatic haemodynamics in rats with overt liver tumour.

机译：明显肝癌大鼠肝脏血液动力学的变化。

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Overt liver tumour was induced in Fisher rats by intraportal administration of 1.6 x 10(7) Walker carcinosarcoma cells. Control groups of rats received similar volumes of dead cells or saline intraportally. All animals were studied at 3 weeks when overt tumour was present. The Hepatic Perfusion Index (HPI) was significantly raised in rats with overt tumour compared to both groups of control animals. Portal flow and portal venous inflow were significantly reduced in the presence of overt tumour but hepatic arterial flow did not alter. These observations suggest that the alteration in the HPI in the presence of overt tumour results from an alteration in portal venous flow and inflow even though the blood supply to the tumour is principally derived from the hepatic artery. The changes in hepatic haemodynamics in the presence of tumour were accompanied by a reduction in portal pressure, an increase in splanchnic vascular resistance and an increase in the degree of arteriovenous shunting through the liver. Portal vascular resistance was unchanged. These findings indicate that the presence of overt hepatic tumour results in gross derangements of hepatic blood flow. These changes must be taken into consideration when attempting to potentiate the delivery of cytotoxic drugs to hepatic tumour by manipulation of hepatic haemodynamics.
机译：通过门静脉内施用1.6 x 10（7）Walker癌肉瘤细胞，可在Fisher大鼠中诱发明显的肝肿瘤。对照组的大鼠经腔内接受相似体积的死细胞或生理盐水。当存在明显的肿瘤时，在第3周研究所有动物。与两组对照动物相比，患有明显肿瘤的大鼠的肝灌注指数（HPI）显着提高。在存在明显肿瘤的情况下，门静脉血流和门静脉血流明显减少，但肝动脉血流没有改变。这些观察结果表明，存在明显肿瘤的情况下，HPI的改变是由于门静脉血流和血流的改变引起的，即使肿瘤的血液供应主要来自肝动脉。在存在肿瘤的情况下，肝血流动力学的变化伴随着门静脉压力的降低，内脏血管阻力的增加以及动静脉通过肝脏的分流程度的增加。门脉血管阻力不变。这些发现表明明显的肝肿瘤的存在导致肝血流的严重紊乱。在尝试通过操纵肝血流动力学增强细胞毒性药物向肝肿瘤的递送时，必须考虑这些变化。

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