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Frequent germline deleterious mutations in DNA repair genes in familial prostate cancer cases are associated with advanced disease

机译：家族性前列腺癌病例中DNA修复基因的频繁种系有害突变与晚期疾病有关

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Background: Prostate cancer (PrCa) is one of the most common diseases to affect men worldwide and among the leading causes of cancer-related death. The purpose of this study was to use second-generation sequencing technology to assess the frequency of deleterious mutations in 22 tumour suppressor genes in familial PrCa and estimate the relative risk of PrCa if these genes are mutated.

机译：背景：前列腺癌（PrCa）是影响全球男性的最常见疾病之一，也是与癌症相关的死亡的主要原因之一。这项研究的目的是使用第二代测序技术评估家族性PrCa中22个抑癌基因的有害突变频率，并评估这些基因突变后PrCa的相对风险。

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期刊名称 British Journal of Cancer
作者
D Leongamornlert; E Saunders; T Dadaev; M Tymrakiewicz; C Goh; S Jugurnauth-Little; I Kozarewa; K Fenwick; I Assiotis; D Barrowdale; K Govindasami; M Guy; E Sawyer; R Wilkinson; A C Antoniou; R Eeles; Z Kote-Jarai;
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年(卷),期 2014(110),6
年度 2014
页码 1663–1672
总页数 10
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
familial prostate cancer DNA repair gene mutations next-generation sequencing relative risk;

机译：家族性前列腺癌;DNA修复基因突变;下一代测序;相对危险;

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专利

1. 新型雄激素受体种系错义突变与非裔男性家族性前列腺癌 [J] . Si-Yi Hu, Tao Liu, Zhen-Zhen Liu, 亚洲男性学杂志：英文版 . 2010,第003期
2. Frequent germline deleterious mutations in DNA repair genes in familial prostate cancer cases are associated with advanced disease [J] . D Leongamornlert, E Saunders, T Dadaev, British Journal of Cancer . 2014,第6期

机译：家族性前列腺癌病例中DNA修复基因的频繁种系有害突变与晚期疾病有关
3. Targeted next generation sequencing identifies functionally deleterious germline mutations in novel genes in early-onset/familial prostate cancer [J] . Paula Paulo, Sofia Maia, Carla Pinto, PLoS Genetics . 2018,第4期

机译：靶向下一代测序可识别早发/家族性前列腺癌中新基因中功能有害的种系突变
4. Targeted next generation sequencing identifies functionally deleterious germline mutations in novel genes in early-onset/familial prostate cancer [J] . Paula Paulo, Sofia Maia, Carla Pinto, PLoS Genetics . 2018,第4期

机译：靶向下一代测序可识别早发/家族性前列腺癌中新基因中功能有害的种系突变
5. Deleterious mutation analysis of BRCA1 based on　clinicopathologic evidence in Chinese familial and sporadic Breast cancer by whole sequencing [C] . Rensheng Lai, Changle Zhu, Lin Xie, International Forum on Progress on Post-Genome Technologies(5'IFPT); 20070910-11; Suzhou(CN) . 2007

机译：基于临床病理证据的中国家族性和散发性乳腺癌BRCA1有害突变全序列分析
6. K-ras andp53 mutations and DNA repair genes polymorphisms as biomarkers for lung cancer. [D] . Gao, Weimin. 2003

机译：K-ras和p53突变和DNA修复基因多态性作为肺癌的生物标记。
7. Targeted next generation sequencing identifies functionally deleterious germline mutations in novel genes in early-onset/familial prostate cancer [O] . Paula Paulo, Sofia Maia, Carla Pinto, 2018

机译：靶向下一代测序可鉴定早发/家族性前列腺癌中新基因中功能有害的种系突变
8. Germline DNA damage repair gene mutations in pancreatic cancer patients with personal/family histories of pancreas/breast/ovarian/prostate cancer in a Japanese population [O] . Tatsuo Hata, Masamichi Mizuma, Fuyuhiko Motoi, 2021

机译：种系DNA损伤在日本人口中胰腺癌/乳腺/卵巢/前列腺癌的个人/家庭历史患者的胰腺癌患者修复基因突变

Frequent germline deleterious mutations in DNA repair genes in familial prostate cancer cases are associated with advanced disease

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