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Human cytomegalovirus IE1 promoter/enhancer drives variable gene expression in all fiber types in transgenic mouse skeletal muscle

机译：人类巨细胞病毒IE1启动子/增强子驱动转基因小鼠骨骼肌中所有纤维类型的可变基因表达

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摘要

BackgroundVersatile transgenic manipulation of skeletal muscle requires knowledge of the expression profiles of diverse promoter/enhancer elements in the transcriptionally specialized fiber types of which muscle is composed. "Universal" viral promoters/enhancers, e.g., cytomegalovirus IE1 (CMV IE1), are of interest as reagents that may drive broad expression. However, a previous study noted a marked heterogeneity of CMV IE1-driven transgene expression among muscle fibers, raising the possibility of fiber-type-restricted expression. The purpose of the present study was to characterize CMV IE1-driven expression in terms of fiber type.

机译：背景技术骨骼肌的多功能转基因操作需要了解组成肌肉的转录专用纤维类型中各种启动子/增强子元件的表达谱。作为可驱动广泛表达的试剂，“通用”病毒启动子/增强子例如巨细胞病毒IE1（CMV IE1）是令人感兴趣的。但是，以前的研究指出，CMV IE1驱动的转基因表达在肌纤维之间存在明显的异质性，从而增加了纤维类型限制表达的可能性。本研究的目的是根据纤维类型表征CMV IE1驱动的表达。

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期刊名称 BMC Genetics
作者
Patricia L Hallauer; Kenneth EM Hastings;
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年(卷),期 2000(1),-1
年度 2000
页码 1
总页数 7
原文格式 PDF
正文语种
中图分类遗传学;
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专利

1. Human cytomegalovirus IE1 promoter/enhancer drives variable gene expression in all fiber types in transgenic mouse skeletal muscle [J] . Patricia L Hallauer, Kenneth EM Hastings BMC Genetics . 2000,第1期

机译：人类巨细胞病毒IE1启动子/增强子驱动转基因小鼠骨骼肌中所有纤维类型的可变基因表达
2. The mouse dystrophin muscle enhancer-1 imparts skeletal muscle, but not cardiac muscle, expression onto the dystrophin Purkinje promoter in transgenic mice. [J] . De Repentigny Y, Marshall P, Worton RG, Human Molecular Genetics . 2004,第22期

机译：小鼠肌营养不良蛋白肌肉增强剂1使转基因小鼠肌营养不良蛋白Purkinje启动子表达骨骼肌而不是心肌。
3. Enhanced transgene expression in the mouse skeletal muscle infected by the adeno-associated viral vector with the human elongation factor 1a promoter and a human chromatin insulator [J] . Mayuyo Mori-Uchino, Takamasa Takeuchi, Isao Murakami, The journal of gene medicine . 2009,第7期

机译：腺相关病毒载体感染人伸长因子1a启动子和染色质绝缘子后在小鼠骨骼肌中增强的转基因表达
4. Growth rate in beef cattle affects adipose gene expression and skeletal muscle fiber type [C] . P. A. Lancaster, M.A. Vaughn, J. D. Starkey, International Symposium on Energy and Protein Metabolism and Nutrition . 2013

机译：肉牛中的生长速率影响脂肪基因表达和骨骼肌纤维型
5. The ocean pout (Macrozoarces americanus) antifreeze protein gene promoter drives expression of antifreeze protein and growth hormone genes in transgenic Atlantic salmon (Salmo salar) [D] . Hobbs, Rodney Stephen 2005

机译：海洋p嘴（Macrozoarces americanus）抗冻蛋白基因启动子驱动转基因大西洋鲑鱼（Salmo salar）中抗冻蛋白和生长激素基因的表达
6. The enhancer domain of the human cytomegalovirus major immediate-early promoter determines cell type-specific expression in transgenic mice. [O] . J F Baskar, P P Smith, G Nilaver, 1996

机译：人巨细胞病毒主要立即启动子的增强子结构域决定了转基因小鼠中细胞类型的特异性表达。
7. Human cytomegalovirus IE1 promoter/enhancer drives variable gene expression in all fiber types in transgenic mouse skeletal muscle [O] . Hallauer Patricia L, Hastings Kenneth EM 2000

机译：人类巨细胞病毒IE1启动子/增强子驱动转基因小鼠骨骼肌中所有纤维类型的可变基因表达

Human cytomegalovirus IE1 promoter/enhancer drives variable gene expression in all fiber types in transgenic mouse skeletal muscle

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