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Multilocus loss of DNA methylation in individuals with mutations in the histone H3 Lysine 4 Demethylase KDM5C

机译：组蛋白H3赖氨酸4去甲基酶KDM5C突变的个体中DNA甲基化的多位点丢失

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BackgroundA number of neurodevelopmental syndromes are caused by mutations in genes encoding proteins that normally function in epigenetic regulation. Identification of epigenetic alterations occurring in these disorders could shed light on molecular pathways relevant to neurodevelopment.

机译：背景许多神经发育综合症是由编码在表观遗传调控中正常起作用的蛋白质的基因突变引起的。在这些疾病中发生的表观遗传学改变的鉴定可以阐明与神经发育相关的分子途径。

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期刊名称 BMC Medical Genomics
作者
Daria Grafodatskaya; Barian HY Chung; Darci T Butcher; Andrei L Turinsky; Sarah J Goodman; Sana Choufani; Yi-An Chen; Youliang Lou; Chunhua Zhao; Rageen Rajendram; Fatima E Abidi; Cindy Skinner; James Stavropoulos; Carolyn A Bondy; Jill Hamilton; Shoshana Wodak; Stephen W Scherer; Charles E Schwartz; Rosanna Weksberg;
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作者单位

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年(卷),期 2013(6),-1
年度 2013
页码 1
总页数 18
原文格式 PDF
正文语种
中图分类遗传学;
关键词
KDM5C DNA methylation H3K4 methylation Intellectual disability;

机译：KDM5C;DNA甲基化;H3K4甲基化;智力障碍;

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专利

1. Multilocus loss of DNA methylation in individuals with mutations in the histone H3 Lysine 4 Demethylase KDM5C [J] . Daria Grafodatskaya, Barian HY Chung, Darci T Butcher, BMC Medical Genomics . 2013,第1期

机译：组蛋白H3赖氨酸4去甲基酶KDM5C突变的个体中DNA甲基化的多位点丢失
2. Histone deacetylase inhibitors stimulate histone H3 lysine 4 methylation in part via transcriptional repression of histone H3 lysine 4 demethylases. [J] . Huang PH, Chen CH, Chou CC, Molecular pharmacology. . 2011,第1期

机译：组蛋白脱乙酰基酶抑制剂部分通过组蛋白H3赖氨酸4脱甲基酶的转录抑制来刺激组蛋白H3赖氨酸4甲基化。
3. KDM6 Demethylase Independent Loss of Histone H3 Lysine 27 Trimethylation during Early Embryonic Development [J] . Karl B. Shpargel, Joshua Starmer, Della Yee, PLoS Genetics . 2014,第8期

机译：KDM6脱甲基酶不依赖组蛋白H3赖氨酸27三甲基化的早期胚胎发育过程中的损失。
4. Complete Trimethylation of Histone Lysine Residues and its Application to the Quantitation of Lysine Methylation Using Mass Spectrometry [C] . Steven Toth, Anthony Berardinelli, Wendell P. Griffith ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：通过质谱法将组蛋白赖氨酸残基的完全三甲基化及其应用于赖氨酸甲基化定量
5. Developmental Control Throughout the Budding Yeast Life Cycle by Jhd2, a JARID family Histone H3 Lysine-4 Demethylase. [D] . Xu, Mengshu. 2014

机译：Jhd2（JARID家族组蛋白H3 Hysine-4 Demethylase）在整个酵母芽生命周期中的发育控制。
6. Histone Deacetylase Inhibitors Stimulate Histone H3 Lysine 4 Methylation in Part Via Transcriptional Repression of Histone H3 Lysine 4 Demethylases [O] . Po-Hsien Huang, Chun-Han Chen, Chih-Chien Chou, -1

机译：组蛋白脱乙酰基酶抑制剂刺激组蛋白H3赖氨酸4甲基化部分通过组蛋白H3赖氨酸4去甲基酶的转录抑制
7. Multilocus loss of DNA methylation in individuals with mutations in the histone H3 Lysine 4 Demethylase KDM5C [O] . Grafodatskaya Daria, Chung Barian HY, Butcher Darci T, 2013

机译：组蛋白H3赖氨酸4去甲基酶KDM5C突变的个体中DNA甲基化的多位点丢失

Multilocus loss of DNA methylation in individuals with mutations in the histone H3 Lysine 4 Demethylase KDM5C

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