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首页> 美国卫生研究院文献>Journal of Physical Therapy Science >Association between mean platelet volume and bone mineral density in patientswith ankylosing spondylitis and diagnostic value of diffusion-weighted magnetic resonanceimaging
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Association between mean platelet volume and bone mineral density in patientswith ankylosing spondylitis and diagnostic value of diffusion-weighted magnetic resonanceimaging

机译：患者平均血小板体积与骨矿物质密度之间的关联强直性脊柱炎及弥散加权磁共振的诊断价值影像学

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[Purpose] The aim this study was to assess the relation between bone mineral density (BMD) and mean platelet volume (MPV) in ankylosing spondylitis (AS) patients, and evaluate the diagnostic role of the diffusion-weighted magnetic resonance imaging (MRI). [Subjects and Methods] Fifty patients diagnosed with AS were divided into two groups on the basis of BMD, a normal group (n=30) and an osteopenic (n=20) group. [Results] Duration of disease in the group with a normal BMD was 10.3±7.0 years, while it was 16.7±12.2 years in the osteopenia group. MPV was high in the osteopenia group, while no significant differences were observed between the groups in terms of apparent diffusion coefficient (ADC) and platelet distribution width (PDW). There was a positive correlation between MPV and duration of disease. Correlations between ADC value and the lumbar T score, femoral neck T score, and duration of disease were insignificant. A negative correlation was observed between BMD and disease duration. [Conclusion] Diffusion-weighted imaging provides valuable results in osteoporosis but is not a suitable technique for evaluating BMD in patients with AS because of the local and systemic inflammatory effects in the musculoskeletal system. The common pathophysiology of atherosclerosis and osteoporosis plays an important role in the negative correlation observed between MPV and BMD in patients with AS.
机译：[目的]本研究旨在评估强直性脊柱炎（AS）患者的骨矿物质密度（BMD）与平均血小板体积（MPV）之间的关系，并评估弥散加权磁共振成像（MRI）的诊断作用。 [对象与方法]根据BMD将50例确诊为AS的患者分为两组，正常组（n = 30）和骨质疏松症（n = 20）组。 [结果] BMD正常组的病程为10.3±7.0年，而骨质减少组为16.7±12.2年。骨质减少组的MPV较高，而各组之间在表观扩散系数（ADC）和血小板分布宽度（PDW）方面未观察到显着差异。 MPV与疾病持续时间呈正相关。 ADC值与腰部T评分，股骨颈T评分和病程之间的相关性无关紧要。 BMD与疾病持续时间之间呈负相关。 [结论]弥散加权成像在骨质疏松症中提供了有价值的结果，但由于肌肉骨骼系统中的局部和全身性炎症作用，因此不适合用于评估AS患者的BMD。动脉粥样硬化和骨质疏松症的常见病理生理在AS患者MPV与BMD之间的负相关中起着重要作用。

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