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Prognostic value of inhibitors of apoptosis proteins (IAPs) and caspases in prostate cancer: caspase-3 forms and XIAP predict biochemical progression after radical prostatectomy

机译：凋亡蛋白（IAPs）和胱氨酸蛋白酶半胱氨酸蛋白酶抑制剂在前列腺癌中的预后价值：caspase-3形式和XIAP预测前列腺癌根治术后的生化进展

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BackgroundThe expression status of apoptotic regulators, such as caspases and inhibitors of apoptosis proteins (IAPs), could reflect the aggressiveness of tumors and, therefore, could be useful as prognostic markers. We explored the associations between tumor expression of caspases and IAPs and clinicopathological features of prostate cancer – clinical and pathological T stage, Gleason score, preoperative serum PSA levels, perineural invasion, lymph node involvement, surgical margin status and overall survival – and evaluated its capability to predict biochemical progression after radical prostatectomy.

机译：背景凋亡调节因子（例如胱天蛋白酶和凋亡蛋白抑制剂（IAP））的表达状态可能反映了肿瘤的侵袭性，因此可用作预后标志物。我们探讨了胱天蛋白酶和IAP的肿瘤表达与前列腺癌的临床病理特征之间的关联-临床和病理学T期，Gleason评分，术前血清PSA水平，神经周浸润，淋巴结受累，手术切缘状态和总体生存率-并评估了其能力预测前列腺癌根治术后的生化进程。

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期刊名称 BMC Cancer
作者
Gonzalo Rodríguez-Berriguete; Norelia Torrealba; Miguel Angel Ortega; Pilar Martínez-Onsurbe; Gabriel Olmedilla; Ricardo Paniagua; Manuel Guil-Cid; Benito Fraile; Mar Royuela;
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年(卷),期 2015(15),-1
年度 2015
页码 809
总页数 9
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
Apoptosis Caspases Biochemical progression Inhibitors of apoptosis proteins Prostate cancer;

机译：凋亡;胱天蛋白酶;生化进程;凋亡蛋白抑制剂;前列腺癌;

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专利

1. Prognostic value of inhibitors of apoptosis proteins (IAPs) and caspases in prostate cancer: caspase-3 forms and XIAP predict biochemical progression after radical prostatectomy [J] . Gonzalo Rodríguez-Berriguete, Norelia Torrealba, Miguel Angel Ortega, BMC Cancer . 2015,第1期

机译：凋亡蛋白（IAPs）和胱氨酸蛋白酶半胱氨酸蛋白酶抑制剂在前列腺癌中的预后价值：caspase-3形式和XIAP预测前列腺癌根治术后的生化进展
2. Elevated expression of caspase-3 inhibitors, survivin and xIAP correlates with low levels of apoptosis in active rheumatoid synovium [J] . Anak ASSK Dharmapatni, Malcolm D Smith, David M Findlay, Arthritis Research . 2009,第1期

机译：Caspase-3抑制剂，survivin和xIAP的高表达与活动性类风湿性滑膜细胞凋亡水平低相关
3. Knockdown of zinc finger protein X-linked inhibits prostate cancer cell proliferation and induces apoptosis by activating caspase-3 and caspase-9 [J] . H Jiang, L Zhang, J Liu, Cancer gene therapy . 2012,第10期

机译：连锁击倒锌指蛋白X抑制前列腺癌细胞增殖并通过激活caspase-3和caspase-9诱导凋亡
4. THE X-LINK INHIBITOR OF APOPTOSIS PROTEIN (XIAP) ENHANCES THE SURVIVABILITY OF C2E7 HYBRIDOMA CELLS UNDER A SERUM DEPRIVED CONDITION [C] . B.T.Tey, K.C. Yap, A. M. Ali, Annual Meeting of the Japanese Association for Animal Cell Technology . 2006

机译：凋亡蛋白（XIAP）的X链路抑制剂增强了C2E7杂交瘤细胞在血清剥夺条件下的活力
5. Importance of the site of positive surgical margin in salvage external beam radiation therapy for biochemical recurrence of prostate cancer after radical prostatectomy [D] . KASHIHARA, Tairo 2019

机译：前列腺癌根治术后前列腺癌生化复发的挽救性外照射治疗中手术切缘阳性部位的重要性
6. α-bisabolol enhances radiotherapy-induced apoptosis in endometrial cancer cells by reducing the effect of XIAP on inhibiting caspase-3 [O] . Dongmei Fang, Hongxin Wang, Min Li, 2019

机译：α-bisabolol通过降低XIAP抑制caspase-3的作用来增强放射疗法诱导的子宫内膜癌细胞凋亡
7. Prognostic value of inhibitors of apoptosis proteins (IAPs) and caspases in prostate cancer: caspase-3 forms and XIAP predict biochemical progression after radical prostatectomy [O] . 2015

机译：凋亡蛋白（IAPs）和胱氨酸蛋白酶半胱氨酸蛋白酶抑制剂在前列腺癌中的预后价值：caspase-3形式和XIAP预测前列腺癌根治术后的生化进展
8. Screening for Small Molecules That Disrupt IAP-Caspases Binding to Activate Caspases and Induce Apoptosis in Breast Cancers [R] . Sun, Y. 2005

机译：筛选破坏Iap-半胱天冬酶结合激活半胱天冬酶并诱导乳腺癌细胞凋亡的小分子

Prognostic value of inhibitors of apoptosis proteins (IAPs) and caspases in prostate cancer: caspase-3 forms and XIAP predict biochemical progression after radical prostatectomy

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