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首页> 外文期刊>BMC Cancer >Prognostic value of inhibitors of apoptosis proteins (IAPs) and caspases in prostate cancer: caspase-3 forms and XIAP predict biochemical progression after radical prostatectomy
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Prognostic value of inhibitors of apoptosis proteins (IAPs) and caspases in prostate cancer: caspase-3 forms and XIAP predict biochemical progression after radical prostatectomy

机译：凋亡蛋白（IAPs）和胱氨酸蛋白酶半胱氨酸蛋白酶抑制剂在前列腺癌中的预后价值：caspase-3形式和XIAP预测前列腺癌根治术后的生化进展

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Background The expression status of apoptotic regulators, such as caspases and inhibitors of apoptosis proteins (IAPs), could reflect the aggressiveness of tumors and, therefore, could be useful as prognostic markers. We explored the associations between tumor expression of caspases and IAPs and clinicopathological features of prostate cancer – clinical and pathological T stage, Gleason score, preoperative serum PSA levels, perineural invasion, lymph node involvement, surgical margin status and overall survival – and evaluated its capability to predict biochemical progression after radical prostatectomy. Methods Protein expression of caspases (procaspase-8, cleaved caspase-8, procaspase-3, cleaved caspase-3, caspase-7 and procaspase-9) and IAPs (cIAP1/2, cIAP2, NAIP, Survivin and XIAP) was analyzed by immunohistochemistry in radical prostatectomy samples from 84 prostate cancer patients. Spearman’s test, Kaplan-Meier curves, and univariate and multivariate Cox proportional hazard regression analysis were performed. Results cIAP1/2, cIAP2, Survivin, procaspase-8, cleaved caspase-8, procaspase-3 and caspase-7 expression correlated with at least one clinicopathological feature of the disease. Patients negative for XIAP, procaspase-3 or cleaved caspase-3 had a significantly worse prognosis. Of note, XIAP, procaspase-3 and cleaved caspase-3 were predictors of biochemical progression independent of Gleason score and pathological T stage. Conclusions Our results indicate that alterations in the expression of IAPs and caspases contribute to the malignant behavior of prostate tumors and suggest that tumor expression of XIAP, procaspase-3 and cleaved caspase-3 may help to identify prostate cancer patients at risk of progression.
机译：背景凋亡调节因子（例如胱天蛋白酶和凋亡蛋白抑制剂（IAP））的表达状态可能反映了肿瘤的侵袭性，因此可用作预后标记。我们探讨了胱天蛋白酶和IAP的肿瘤表达与前列腺癌的临床病理特征之间的关联-临床和病理学T期，Gleason评分，术前血清PSA水平，神经周浸润，淋巴结受累，手术切缘状态和总体生存率-并评估了其能力预测前列腺癌根治术后的生化进程。方法分析caspases（procaspase-8，裂解的caspase-8，procaspase-3，裂解的caspase-3，caspase-7和procaspase-9）和IAP（cIAP1 / 2，cIAP2，NAIP，Survivin和XIAP）的蛋白表达。 84位前列腺癌患者根治性前列腺切除术样本中的免疫组织化学。进行了Spearman检验，Kaplan-Meier曲线以及单变量和多变量Cox比例风险回归分析。结果cIAP1 / 2，cIAP2，Survivin，procaspase-8，裂解的caspase-8，procaspase-3和caspase-7表达与该疾病的至少一种临床病理特征相关。 XIAP，procaspase-3或caspase-3裂解阴性的患者的预后明显较差。值得注意的是，XIAP，procaspase-3和裂解的caspase-3是生物化学进程的预测因子，与Gleason评分和病理性T期无关。结论我们的结果表明，IAP和caspases表达的改变有助于前列腺肿瘤的恶性行为，并表明XIAP，procaspase-3和caspase-3裂解的肿瘤表达可能有助于鉴定有进展风险的前列腺癌患者。

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