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Anti-inflammatory and antinociceptive activities of Bauhinia monandra leaf lectin

机译：紫荆花凝集素的抗炎和镇痛活性

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A galactose-specific lectin from Bauhinia monandra leaves (BmoLL) has been purified through ammonium sulfate fractionation followed by guar gel affinity chromatography column. This study aimed to evaluate the potential anti-inflammatory and antinociceptive activity of pure BmoLL in mice. Anti-inflammatory activity was evaluated by 1% carrageenan-induced inflammation in mice treated with BmoLL. Acetic acid-induced abdominal writhing and hot plate methods evaluated antinociceptive activity. BmoLL significantly inhibited the carrageenan-induced paw edema by 47% (30 mg/kg) and 60.5% (60 mg/kg); acetylsalicylic acid (ASA, 100 mg/kg) showed inhibition of 70.5%, in comparison to controls. Leukocyte migration, an immune response to the inflammation process, was significantly reduced in presence of BmoLL; in mice treated with ASA the decrease in leukocyte migration was similar to 15 mg/kg of the lectin. BmoLL at doses of 15, 30 and 60 mg/kg significantly reduced the number of animal contortions by 43.1, 50.1 and 71.3%, respectively. BmoLL leukocyte migration was significantly reduced; in mice treated with ASA the decrease in leukocyte migration was similar to 15 mg/kg of the lectin. BmoLL at doses of 15, 30 and 60 mg/kg significantly reduced the number of animal contortions by 43.1, 50.1 and 71.3%, respectively. The lectin (30 and 60 mg/kg) showed a significant effect in the hot plate assay. BmoLL anti-inflammatory and antinociceptive effects were dose-dependent. The search for new and natural compounds, with minimal side effects, to control pain and inflammation, is constantly increasing. BmoLL has great potential as a natural anti-inflammatory product that can be explored for pharmacological purposes.
机译：来自洋紫荆叶（BmoLL）的半乳糖特异性凝集素已通过硫酸铵分级分离，然后通过瓜尔胶亲和色谱柱进行了纯化。这项研究旨在评估纯BmoLL在小鼠中的潜在抗炎和镇痛活性。通过BmoLL处理的小鼠中1％角叉菜胶诱导的炎症来评估抗炎活性。乙酸引起的腹部扭动和热板法评估了抗伤害感受活性。 BmoLL显着抑制角叉菜胶诱发的爪水肿47％（30 mg / kg）和60.5％（60μmg/ kg）;与对照组相比，乙酰水杨酸（ASA，100 mg / kg）显示抑制率为70.5％。在存在BmoLL的情况下，白细胞迁移（一种针对炎症过程的免疫反应）显着降低；在用ASA处理的小鼠中，白细胞迁移的减少类似于15 mg / kg的凝集素。分别以15、30和60 mg / kg的剂量服用BmoLL可以显着减少动物扭曲的数量，分别为43.1％，50.1％和71.3％。 BmoLL白细胞迁移明显减少；在用ASA处理的小鼠中，白细胞迁移的减少类似于15 mg / kg的凝集素。分别以15、30和60 mg / kg的剂量服用BmoLL可以显着减少动物扭曲的数量，分别为43.1％，50.1％和71.3％。凝集素（30和60 mg / kg）在热板测定中显示出显着效果。 BmoLL的抗炎和镇痛作用是剂量依赖性的。寻找新的，具有最小副作用，以控制疼痛和炎症的天然化合物的需求正在不断增加。 BmoLL作为天然抗炎产品具有巨大的潜力，可用于药理学目的。

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