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An association study of DRD2 and COMT polymorphisms with novelty seeking and harm avoidance scores in two independent samples of depressed patients

机译:在两个抑郁症患者的独立样本中DRD2和COMT基因多态性与寻求新颖性和避免伤害得分的关联性研究

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摘要

BackgroundIt was recently reported that an interaction of the dopamine D2 receptor (DRD2) and catechol-O-methyltransferase (COMT) influences the behavioural approach system – as measured using Carver and White's Behavioural Inhibition and Behavioural Approach System (BIS/BAS) scales – in a sample of healthy German subjects. The Temperament and Character Inventory (TCI), in particular the novelty seeking (NS) and harm avoidance (HA) scales, correlates moderately with the BIS/BAS measure. This study aimed to examine support for an association of DRD2 and COMT with behavioural activation, using the TCI within two independent samples of depressed outpatients (for both samples n = 146).
机译:背景最近有报道称,多巴胺D2受体(DRD2)和儿茶酚-O-甲基转移酶(COMT)的相互作用会影响行为方式系统-如使用Carver和White的行为抑制和行为方式系统(BIS / BAS)量表所测量的。健康的德国受试者的样本。气质和性格量表(TCI),尤其是寻求新奇(NS)和避免伤害(HA)量表,与BIS / BAS测度适度相关。这项研究的目的是在两个独立的抑郁门诊患者样本中(两个样本均为n = 146)使用TCI来检查对DRD2和COMT与行为激活相关性的支持。

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