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首页> 美国卫生研究院文献>The Journal of Neuroscience >Dissociable Contributions of the Orbitofrontal and Infralimbic Cortex to Pavlovian Autoshaping and Discrimination Reversal Learning: Further Evidence for the Functional Heterogeneity of the Rodent Frontal Cortex
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Dissociable Contributions of the Orbitofrontal and Infralimbic Cortex to Pavlovian Autoshaping and Discrimination Reversal Learning: Further Evidence for the Functional Heterogeneity of the Rodent Frontal Cortex

机译：眶额和下肢皮层对巴甫洛夫自动成形和歧视逆向学习的可分解贡献：啮齿类动物额叶皮层功能异质性的进一步证据

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To examine possible heterogeneity of function within the ventral regions of the rodent frontal cortex, the present study compared the effects of excitotoxic lesions of the orbitofrontal cortex (OFC) and the infralimbic cortex (ILC) on pavlovian autoshaping and discrimination reversal learning. During the pavlovian autoshaping task, in which rats learn to approach a stimulus predictive of reward [conditional stimulus (CS+)], only the OFC group failed to acquire discriminated approach but was unimpaired when preoperatively trained. In the visual discrimination learning and reversal task, rats were initially required to discriminate a stimulus positively associated with reward. There was no effect of either OFC or ILC lesions on discrimination learning. When the stimulus-reward contingencies were reversed, both groups of animals committed more errors, but only the OFC-lesioned animals were unable to suppress the previously rewarded stimulus-reward association, committing more “stimulus perseverative” errors. In contrast, the ILC group showed a pattern of errors that was more attributable to “learning” than perseveration. These findings suggest two types of dissociation between the effects of OFC and ILC lesions: (1) OFC lesions impaired the learning processes implicated in pavlovian autoshaping but not instrumental simultaneous discrimination learning, whereas ILC lesions were unimpaired at autoshaping and their reversal learning deficit did not reflect perseveration, and (2) OFC lesions induced perseverative responding in reversal learning but did not disinhibit responses to pavlovian CS-. In contrast, the ILC lesion had no effect on response inhibitory control in either of these settings. The findings are discussed in the context of dissociable executive functions in ventral sectors of the rat prefrontal cortex.
机译：为了检查啮齿动物额叶皮层腹侧区域内功能的异质性，本研究比较了眶额叶皮层（OFC）和下缘皮层（ILC）的兴奋毒性损伤对帕夫洛夫自动成形和辨别力反转学习的影响。在帕夫洛夫式自动塑形任务中，大鼠学会了学习预测奖励的刺激[条件性刺激（CS + ）]，只有OFC组未能获得辨别性的方法，但在术前训练中并未受到损害。在视觉识别学习和逆转任务中，最初要求大鼠区分与奖赏正相关的刺激。 OFC或ILC病变对歧视性学习没有影响。当刺激与奖励的偶发性被逆转时，两组动物都犯了更多的错误，但只有OFC受损害的动物无法抑制先前奖励的刺激与奖励的关联，从而犯下了更多的“刺激性持久性”错误。相比之下，ILC组显示出一种错误模式，这种错误模式更多地归因于“学习”而不是毅力。这些发现表明，OFC和ILC病变的作用之间存在两种类型的分离：（1）OFC病变损害了帕夫洛夫自动整形相关的学习过程，但不影响工具性的同时歧视学习，而ILC病变在自动整形方面没有受到损害，并且其逆向学习缺陷没有反映了持之以恒；（2）OFC病变在逆向学习中诱导了持续性反应，但没有抑制对帕夫洛夫CS -的反应。相反，在这两种情况下，ILC病变对反应抑制控制均无影响。在大鼠前额叶皮层腹侧部分可分离的执行功能的背景下讨论了这些发现。

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