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首页> 美国卫生研究院文献>The Journal of Neuroscience >Complementary Roles of Human Hippocampal Subregions during Retrieval of Spatiotemporal Context
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Complementary Roles of Human Hippocampal Subregions during Retrieval of Spatiotemporal Context

机译：时空上下文检索过程中人类海马亚区的补充作用。

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Current evidence strongly supports the central involvement of the human medial temporal lobes (MTL) in storing and retrieving memories for recently experienced events. However, a critical remaining question regards exactly how the hippocampus and surrounding cortex represents spatiotemporal context defining an event in memory. Competing accounts suggest that this process may be accomplished by the following: (1) an overall increase in neural similarity of representations underlying spatial and temporal context, (2) a differentiation of competing spatiotemporal representations, or (3) a combination of the two processes, with different subregions performing these two functions within the MTL. To address these competing proposals, we used high-resolution functional magnetic resonance imaging targeting the MTL along with a multivariate pattern similarity approach with 19 participants. While undergoing imaging, participants performed a task in which they retrieved spatial and temporal contextual representations from a recently learned experience. Results showed that successfully retrieving spatiotemporal context defining an episode involved a decrease in pattern similarity between putative spatial and temporal contextual representations in hippocampal subfields CA2/CA3/DG, whereas the parahippocampal cortex (PHC) showed the opposite pattern. These findings could not be accounted for by differences in univariate activations for complete versus partial retrieval nor differences in correlations for correct or incorrect retrieval. Together, these data suggest that the CA2/CA3/DG serves to differentiate competing contextual representations, whereas the PHC stores a comparatively integrated trace of scene-specific context, both of which likely play important roles in successful episodic memory retrieval.
机译：当前证据强烈支持人类内侧颞叶（MTL）在存储和检索最近经历的事件的记忆中的重要参与。然而，还有一个关键的问题仍然是关于海马体和周围皮层如何代表时空背景来定义记忆事件。相互竞争的说明表明，可以通过以下方式完成此过程：（1）时空背景下表示形式的神经相似性整体增加，（2）时空竞争形式的区分，或（3）两种过程的组合，由不同的子区域在MTL中执行这两项功能。为了解决这些竞争性提案，我们使用了针对MTL的高分辨率功能磁共振成像以及具有19个参与者的多变量模式相似性方法。在进行成像时，参与者执行了一项任务，在该任务中，他们从最近学到的经验中检索了空间和时间的上下文表示。结果表明，成功检索定义一个情节的时空情境涉及在海马子区CA2 / CA3 / DG中假定的时空情境表示之间的模式相似性降低，而海马旁皮质（PHC）则显示相反的模式。这些发现无法通过完全检索与部分检索的单变量激活差异或正确或错误检索的相关性差异来解释。总之，这些数据表明，CA2 / CA3 / DG可用来区分竞争性上下文表示，而PHC存储了场景特定上下文的相对集成的痕迹，这两种痕迹在成功的情节记忆检索中都可能发挥重要作用。

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