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首页> 美国卫生研究院文献>Balkan Journal of Medical Genetics : BJMG >Epigenetic Signature of Chronic Maternal Stress Load During Pregnancy Might be a Potential Biomarker for Spontaneous Preterm Birth
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Epigenetic Signature of Chronic Maternal Stress Load During Pregnancy Might be a Potential Biomarker for Spontaneous Preterm Birth

机译：妊娠期间慢性母体应激负荷的表观遗传特征可能是自发性早产的潜在生物标志物

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Preterm birth is the leading cause of mortality in newborn infants and can lead to significant neonatal morbidities. Spontaneous preterm birth accounts for at least 50.0% of all preterm births. We argue that chronic maternal stress load, which is an important risk factor for spontaneous preterm birth, could be represented by epigenetic signature of several specific genetic loci in the mother’s blood. A literature search was done in PubMed with the following keywords: “DNA methylation,” “epigenetics,” “maternal stress” and “preterm birth” from year 2000 to 2017. We suggest that these genetic loci might be related to vulnerability and hypersensibility of stress response during pregnancy in women with preterm births. The mother’s epi-genetic stress bioprofile was supposed to be a result of chronic maternal stress load since her birth. This epigenetic bioprofile might also be a potential biomarker for spontaneous preterm birth. DNA methylation changes are tissue-specific and human stress response manifests mostly through the central nervous system (CNS). Nevertheless, we found evidence that methylation changes of DNA isolated from blood leucocytes might be a reliable measure of stress-related epigenetic changes that occur in the CNS. Evaluating biological mechanisms through the development of simple assays based on epigenetic changes to measure chronic stress loads in expectant mothers can lead to our ability to prepare more effective measures for the prevention of preterm births, as well as leading to more effective treatment strategies for both expectant mothers and their newborns.
机译：早产是新生儿死亡的主要原因，并可能导致重大的新生儿发病率。自发性早产至少占所有早产的50.0％。我们认为，慢性产妇压力负荷是自发性早产的重要危险因素，可以通过母亲血液中几个特定遗传位点的表观遗传学特征来表示。从2000年到2017年，在PubMed中使用以下关键词进行了文献检索：“ DNA甲基化”，“表观遗传学”，“母亲压力”和“早产”。我们建议这些基因位点可能与糖尿病的易感性和超敏性有关。早产妇女怀孕期间的应激反应。母亲的表观遗传压力生物特征被认为是自她出生以来长期的母亲压力负荷的结果。这种表观遗传的生物概况也可能是自发性早产的潜在生物标记。 DNA甲基化变化是组织特异性的，人的应激反应主要通过中枢神经系统（CNS）表现出来。然而，我们发现有证据表明从血液白细胞分离的DNA的甲基化变化可能是中枢神经系统中与压力相关的表观遗传变化的可靠度量。通过基于表观遗传学变化的简单测定方法的开发来评估生物学机制，以测量准妈妈的慢性压力负荷，可以使我们有能力制定更有效的措施来预防早产，并为两种准妈妈提供更有效的治疗策略母亲和他们的新生儿。

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