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首页> 外文期刊>Balkan journal of medical genetics: BJMG >EPIGENETIC SIGNATURE OF CHRONIC MATERNAL STRESS LOAD DURING PREGNANCY MIGHT BE A POTENTIAL BIOMARKER FOR SPONTANEOUS PRETERM BIRTH
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EPIGENETIC SIGNATURE OF CHRONIC MATERNAL STRESS LOAD DURING PREGNANCY MIGHT BE A POTENTIAL BIOMARKER FOR SPONTANEOUS PRETERM BIRTH

机译：妊娠期间慢性母体应激载荷的表观遗传签名可能是自发早产的潜在生物标志物

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摘要

Preterm birth is the leading cause of mortality in newborn infants and can lead to significant neonatal morbidities. Spontaneous preterm birth accounts for at least 50.0% of all preterm births. We argue that chronic maternal stress load, which is an important risk factor for spontaneous preterm birth, could be represented by epigenetic signature of several specific genetic loci in the mother's blood. A literature search was done in PubMed with the following keywords: "DNA methylation," "epigenetics," "maternal stress" and "preterm birth" from year 2000 to 2017. We suggest that these genetic loci might be related to vulnerability and hypersensibility of stress response during pregnancy in women with preterm births. The mother's epi-genetic stress bioprofile was supposed to be a result of chronic maternal stress load since her birth. This epigenetic bioprofile might also be a potential biomarker for spontaneous preterm birth. DNA methylation changes are tissue-specific and human stress response manifests mostly through the central nervous system (CNS). Nevertheless, we found evidence that methylation changes of DNA isolated from blood leucocytes might be a reliable measure of stress-related epigenetic changes that occur in the CNS. Evaluating biological mechanisms through the development of simple assays based on epigenetic changes to measure chronic stress loads in expectant mothers can lead to our ability to prepare more effective measures for the prevention of preterm births, as well as leading to more effective treatment strategies for both expectant mothers and their newborns.
机译：早产是新生儿死亡率的主要原因，可以导致显着的新生儿生命。自发早产占所有早产的50.0％。我们认为，慢性产妇应激载荷，这是自发早产的重要危险因素，可以通过母亲血液中几种特定遗传基因座的表观遗传签名来表示。文学搜索是在Pubmed中进行的以下关键词：“DNA甲基化”，“表观生物学，”母体应激“和2000年的”产妇胁迫“和”早产“。我们建议这些遗传基因座可能与脆弱性和超敏性有关早产孕妇妊娠期应激反应。母亲的外延遗传胁迫生物遗传学是由于她出生以来慢性母体应激载荷的结果。这种表观遗传生物破产也可能是用于自发早产的潜在生物标志物。 DNA甲基化变化是组织特异性，人应激反应主要通过中枢神经系统（CNS）。然而，我们发现从血液白细胞分离的DNA的甲基化变化可能是CNS中发生的应激相关的表观遗传变化的可靠措施。通过基于表观遗传变化的简单测定来评估生物机制，以测量预期母亲的慢性应激负荷可以导致我们制定更有效的预防早产的措施的能力，以及导致既有预期的疗效更有效的治疗策略母亲和他们的新生儿。

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