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首页> 美国卫生研究院文献>Annals of Surgery >Comparison of the fecal microflora of Seventh-Day Adventists with individuals consuming a general diet. Implications concerning colonic carcinoma.
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Comparison of the fecal microflora of Seventh-Day Adventists with individuals consuming a general diet. Implications concerning colonic carcinoma.

机译：基督复临安息日会与食用普通饮食的人的粪便菌群比较。对结肠癌的影响。

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Qualitative and quantitative fecal microflora was studied in a double blind fashion in 28 subjects. Fourteen were Seventh-Day Adventists, who were strict vegetarians, while the remaining 14 subjects were individuals consuming a general western diet. No statistically significant differences were identified in the fecal microflora of the two groups. The bacteriologic analysis included total aerobes and total anaerobes as well as each of the major fecal aerobes and anaerobes. This study seems to indicate that the dietary intake of animal fat and protein does not significantly alter the fecal microflora, a possibility which has previously been suggested as being part of the explanation for the higher incidence of colonic carcinoma in those who consume meat compared with vegetarians. It does not, however, invalidate the concept that dietary animal fat does increase bile acid degradation within the gastrointestinal tract, a factor which has been related to colon cancer. Future studies should be directed at identifying the factors that may be present in the gastrointestinal tracts of vegetarians which modify the ability of their colonic microflora to degrade bile acids, an essential step in the production of intraluminal carcinogens or co-carcinogens.
机译：定性和定量粪便微生物区系以双盲方式研究了28位受试者。基督复临安息日会中有14人是严格的素食主义者，其余14人是食用西餐的个人。在两组的粪便菌群中没有发现统计学上的显着差异。细菌学分析包括总需氧菌和总厌氧菌以及主要的粪便需氧菌和厌氧菌。这项研究似乎表明，饮食中动物脂肪和蛋白质的摄入量不会显着改变粪便微生物区系，此前有人认为这种可能性是食用肉类者与素食者相比结肠癌发病率更高的原因之一。 。然而，这并没有使饮食动物脂肪确实会增加胃肠道内胆汁酸降解的概念无效，这是与结肠癌有关的一个因素。未来的研究应着眼于确定素食者胃肠道中可能存在的因素，这些因素会改变其结肠菌群降解胆汁酸的能力，这是腔内致癌物或共致癌物生产的重要步骤。

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