首页> 美国卫生研究院文献>The American Journal of Tropical Medicine and Hygiene >The Changing Epidemiology of Human T-Cell Lymphotropic Virus Type 1 Infection in Peruvian Female Sex Workers 1993–2010
【2h】

The Changing Epidemiology of Human T-Cell Lymphotropic Virus Type 1 Infection in Peruvian Female Sex Workers 1993–2010

机译:秘鲁女性工作人员的人类T细胞淋巴病毒1型感染的流行病学变化1993-2010年

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

Human T-cell lymphotropic virus type 1 (HTLV-1) was the first human retrovirus to be reported and is associated with neoplastic, neurological, autoimmune, and infectious complications. HTLV-1 is endemic in Peru, with the highest prevalence reported among commercial sex workers. Seroprevalence data collected from Peruvian female sex workers (FSWs) working in Callao over three study periods between 1993 and 2010 were used to examine the secular trend in HTLV-1 prevalence. Between 1993 and 2010, the prevalence of HTLV-1 decreased significantly from 14.5% to 3.1% (P < 0.01). The prevalence of HTLV-1 seropositivity differed significantly by birth cohort (1922–1959, 1960–1969, 1970–1979, and 1980–1992), and for each of the four birth cohorts, the prevalence did not significantly decrease by screening year (P > 0.07). There were no cases of HTLV-1 detected among FSW born after 1979 (N = 224). Participant characteristics associated with HTLV-1 seropositivity were birth in the Andes Mountains region, age, increased time in sex work, younger age of starting sex work, and human immunodeficiency virus (HIV) seropositivity. The secular trend in declining prevalence persisted after adjustment for age, time in sex work, place of birth, and HIV serostatus, with the odds of HTLV-1 infection decreasing approximately 16% per year (adjusted odds ratio = 0.84, 95% confidence interval = 0.78, 0.90). The increasing use of condoms by later birth cohorts noted in our analysis, as well as the increasing availability of free condoms provided by the Peruvian government—which started in the late 1980s before this study— may have been responsible for declining HTLV seroprevalence.
机译:人类T细胞淋巴病毒1型(HTLV-1)是第一个被报道的人类逆转录病毒,并与肿瘤,神经,自身免疫和感染性并发症相关。 HTLV-1在秘鲁是地方病,据报道在商业性工作者中患病率最高。从1993年至2010年的三个研究期间,从在卡亚俄工作的秘鲁女性性工作者(FSW)收集的血清流行率数据用于检验HTLV-1流行的长期趋势。在1993年至2010年之间,HTLV-1的患病率从14.5%显着下降到3.1%(P <0.01)。 HTLV-1血清阳性的患病率因出生队列而异(1922-1959年,1960-1969年,1970-1979年和1980-1992年),并且对于四个出生队列中的每一个,通过筛查年份均没有显着降低患病率( P> 0.07)。在1979年以后出生的FSW中未检测到HTLV-1病例(N = 224)。与HTLV-1血清阳性有关的参与者特征包括安第斯山脉地区的出生,年龄,从事性工作的时间增加,从事性工作的年龄较小以及人类免疫缺陷病毒(HIV)血清阳性。在调整年龄,性工作时间,出生地点和HIV血清状况之后,流行率持续下降的长期趋势仍然存在,HTLV-1感染的几率每年降低约16%(调整后的几率= 0.84,95%置信区间= 0.78,0.90)。我们的分析指出,后来出生的人群越来越多地使用安全套,秘鲁政府提供的免费安全套的可用性不断增加(此研究开始于1980年代末),这可能是造成HTLV血清阳性率下降的原因。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号