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Near Full-Length Genome Sequence of a Novel HIV Type 1 Second-Generation Recombinant Form (CRF01_AE/CRF07_BC) Identified Among Men Who Have Sex with Men in Jilin China

机译：在吉林省与男性发生性关系的男性中鉴定出新型HIV 1型第二代重组形式（CRF01_AE / CRF07_BC）的近全长基因组序列

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摘要

We report here a novel HIV-1 second-generation recombinant form (CRF01_AE/CRF07_BC) composed of CRF01_AE and CRF07_BC, identified among men who have sex with men (MSM) in Jilin, with four breakpoints observed in the pol, vif, and vpr genes. The CRF01_AE regions of the recombinant were clustered with the CRF01_AE lineage, which is mainly circulating among MSM in northern China, with the support of 100% bootstrap value, indicating that the parental origin of the CRF01_AE regions was from MSM, in which recombination events may be more likely to occur. To the best of our knowledge, this is the first detection of a novel HIV-1 second-generation recombinant form (CRF01AE/CRF07_BC) in Jilin, which indicates active transmission networks of HIV-1 infection among MSM in the region. Therefore, it is necessary to continue monitoring the molecular epidemiology of HIV-1 among MSM in Jilin to obtain a better understanding of the transmission and potential public health impact of HIV-1 among MSM in the region.

机译：我们在这里报告了一种新的HIV-1第二代重组形式（CRF01_AE / CRF07_BC），由CRF01_AE和CRF07_BC组成，在吉林省与男性（MSM）发生性关系的男性中确定，在pol，vif和vpr中观察到四个断点基因。重组子的CRF01_AE区与CRF01_AE谱系聚在一起，该谱系主要在中国北方的MSM中传播，并具有100％的自举值，表明CRF01_AE区的亲本起源于MSM，其中可能发生重组事件更有可能发生。据我们所知，这是吉林首次检测到新型HIV-1第二代重组体（CRF01AE / CRF07_BC），这表明该地区MSM之间HIV-1感染的活跃传播网络。因此，有必要继续监测吉林省MSM中HIV-1的分子流行病学，以更好地了解该地区MSM中HIV-1的传播和潜在的公共卫生影响。

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期刊名称 AIDS Research and Human Retroviruses
作者
Xingguang Li; Chuanyi Ning; Xiang He; Yao Yang; Hui Xing; Kunxue Hong; Yiming Shao; Rongge Yang;
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年(卷),期 -1(29),12
年度 -1
页码 1604–1608
总页数 5
原文格式 PDF
正文语种
中图分类免疫学;病毒传染病;人体病毒学（致病病毒）;病毒（滤过性病毒）;
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专利

1. Near Full-Length Genome Sequence of a Novel HIV-1 Second-Generation Recombinant Form (CRF01_AE/CRF07_BC) Detected Among Men Who Have Sex with Men in Tianjin, China [J] . Ping Ma, Zhangwen Ge, Yi Feng, AIDS Research and Human Retroviruses . 2019,第2期

机译：在与中国天津有关系的男性中检测到新型HIV-1第二代重组形式（CRF01_AE / CRF07_BC）的近全长基因组序列
2. Near full-length genome sequence of a Novel HIV Type 1 second-generation recombinant form (CRF01-AE/CRF07-BC) identified among men who have sex with men in Jilin, China [J] . LiX., NingC., HeX., AIDS Research and Human Retroviruses . 2013,第12期

机译：在吉林省与男性发生性行为的男性中鉴定出新型HIV 1型第二代重组体（CRF01-AE / CRF07-BC）的近全长基因组序列
3. Near Full-Length Genome Sequence of a Novel HIV-1 Second-Generation Recombinant Form (CRF01_AE/CRF07_BC) Detected Among Blood Donors in North China [J] . He Wei, Han Xiaoxu, An Minghui, AIDS Research and Human Retroviruses . 2017,第12期

机译：在华北地区献血者中检测到新型HIV-1第二代重组形式（CRF01_AE / CRF07_BC）的全长基因组序列
4. An Information Theoretic Approach to the Study of Genome Sequences: An Application to the Evolution of HIV [C] . Masanori Ohya Third International Conference on Unconventional Models of Computation UMC 2002, Oct 15-19, 2002, Kobe, Japan . 2002

机译：信息理论方法研究基因组序列：在HIV进化中的应用
5. Using geographic information system (GIS) to identify clustered elevated rates of HIV and syphilis co-infection in men who have sex with men (MSM) in selected areas in Texas and New York: Comparison and identification of core areas for targeted prevention [D] . Morrison-Jones, June 2015

机译：使用地理信息系统（GIS）识别德克萨斯州和纽约州特定地区与男性发生性关系的男性（MSM）的艾滋病毒和梅毒合并感染的聚集率上升：有针对性的预防核心区域的比较和识别
6. Near Full-Length Genome Sequence of a Novel HIV-1 Recombinant Form (CRF01_AE/B) Detected Among Men Who Have Sex with Men in Jilin Province China [O] . Xingguang Li, Yi Feng, Yao Yang, -1

机译：吉林省男男性接触者中检测到的新型HIV-1重组形式（CRF01_AE / B）的近全长基因组序列。
7. Identification of a Novel HIV-1 Second-Generation Recombinant Form (CRF01_AE/CRF07_BC) in Jilin, China [O] . Yi Feng, Xingguang Li, Xihui Zang, 2014

机译：鉴定吉林省的新型HIV-1第二代重组形式（CRF01_AE / CRF07_BC）

Near Full-Length Genome Sequence of a Novel HIV Type 1 Second-Generation Recombinant Form (CRF01_AE/CRF07_BC) Identified Among Men Who Have Sex with Men in Jilin China

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