Activation of TRPV1 by capsaicin induces functional Kinin B1 receptor in rat spinal cord microglia

机译：辣椒素激活TRPV1可诱导大鼠脊髓小胶质细胞功能性激肽B1受体

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BackgroundThe kinin B1 receptor (B1R) is upregulated by pro-inflammatory cytokines and oxydative stress, which are enhanced by transient receptor potential vanilloid subtype 1 (TRPV1) activation. To examine the link between TRPV1 and B1R in inflammatory pain, this study aimed to determine the ability of TRPV1 to regulate microglial B1R expression in the spinal cord dorsal horn, and the underlying mechanism.

机译：背景激肽B1受体（B1R）被促炎性细胞因子和氧化应激上调，而瞬态受体潜在的香草样亚型1（TRPV1）激活则增强了激肽B1受体。为了研究炎性疼痛中TRPV1和B1R之间的联系，本研究旨在确定TRPV1调节脊髓背角中小胶质细胞B1R表达的能力及其潜在机制。

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期刊名称 Journal of Neuroinflammation
作者
Sébastien Talbot; Jenny Pena Dias; Karim Lahjouji; Maurício Reis Bogo; Maria Martha Campos; Pierrette Gaudreau; Réjean Couture;
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作者单位

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年(卷),期 2012(9),-1
年度 2012
页码 16
总页数 17
原文格式 PDF
正文语种
中图分类神经科学;
关键词
Bradykinin B1 receptors TRPV1 capsaicin oxidative stress thermal hyperalgesia;

机译：缓激肽;B1受体;TRPV1;辣椒素;氧化应激;热痛觉过敏;

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专利

1. Activation of TRPV1 by capsaicin induces functional Kinin B₁receptor in rat spinal cord microglia [J] . Sébastien Talbot, Jenny Pena Dias, Karim Lahjouji, Journal of neuroinflammation . 2012,第3期

机译：辣椒素激活TRPV1可诱导大鼠脊髓小胶质细胞中功能性激肽B _{1 受体}
2. Expression of kinin B1 receptors in the spinal cord of streptozotocin-diabetic rat. [J] . Couture R Neuroreport . 2004,第16期

机译：激肽素-糖尿病大鼠脊髓中激肽B1受体的表达。
3. Effects of alpha-lipoic acid on kinin B1 and B2 receptor binding sites in the spinal cord of chronically angiotensin-treated rats. [J] . Petcu M, Ongali B, El Midaoui A, Peptides: An International Journal . 2005,第8期

机译：α-硫辛酸对慢性血管紧张素治疗大鼠脊髓中激肽B1和B2受体结合位点的影响。
4. Selective nanovector mediated treatment of activated microglia in spinal cord injury [C] . Filippo Rossi, Simonetta Papa, Raffaele Ferrari, World biomaterials congress . 2016

机译：选择性纳米载体介导的活化小胶质细胞治疗脊髓损伤
5. Structural Studies on Ligand and Lipid Modulation of the Capsaicin Receptor, TRPV1 [D] . Gao, Yuan 2017

机译：辣椒素受体TRPV1的配体和脂质调节的结构研究
6. Effects of kinin B1 and B2 receptor antagonists on overactive urinary bladder syndrome induced by spinal cord injury in rats [O] . Stefânia Forner, Edinéia L Andrade, Alessandra C Martini, 2012

机译：激肽B1和B2受体拮抗剂对大鼠脊髓损伤所致膀胱过度活动综合征的影响
7. Activation of TRPV1 by capsaicin induces functional Kinin B1 receptor in rat spinal cord microglia [O] . Sébastien Talbot, Jenny Pena Dias, Karim Lahjouji, 2012

机译：辣椒素激活TRPV1可诱导大鼠脊髓小胶质细胞功能性激肽B1受体

Activation of TRPV1 by capsaicin induces functional Kinin B1 receptor in rat spinal cord microglia

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