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Neuronal uptake of anti-Hu antibody but not anti-Ri antibody leads to cell death in brain slice cultures

机译：神经元摄取抗Hu抗体而不是抗Ri抗体会导致脑切片培养物中的细胞死亡

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摘要

BackgroundAnti-Hu and anti-Ri antibodies are paraneoplastic immunoglobulin (Ig)G autoantibodies which recognize cytoplasmic and nuclear antigens present in all neurons. Although both antibodies produce similar immunohistological labeling, they recognize different neuronal proteins. Both antibodies are associated with syndromes of central nervous system dysfunction. However, the neurological deficits associated with anti-Hu antibody are associated with neuronal death and are usually irreversible, whereas neurological deficits in patients with anti-Ri antibody may diminish following tumor removal or immunosuppression.

机译：背景抗Hu和抗Ri抗体是副肿瘤免疫球蛋白（Ig）G自身抗体，可识别所有神经元中存在的细胞质和核抗原。尽管两种抗体产生相似的免疫组织学标记，但它们识别不同的神经元蛋白。两种抗体均与中枢神经系统功能障碍综合征相关。但是，与抗Hu抗体相关的神经功能缺损与神经元死亡有关，并且通常是不可逆的，而抗Ri抗体患者的神经功能缺损可能会在肿瘤切除或免疫抑制后减轻。

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期刊名称 Journal of Neuroinflammation
作者
John E Greenlee; Susan A Clawson; Kenneth E Hill; Blair Wood; Stacey L Clardy; Ikuo Tsunoda; Troy D Jaskowski; Noel G Carlson;
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作者单位

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年(卷),期 2014(11),-1
年度 2014
页码 160
总页数 15
原文格式 PDF
正文语种
中图分类神经科学;
关键词
Paraneoplastic syndromes Anti-Hu antibody Anti-Ri antibody Neurons Brain slice cultures Organotypic brain cultures Cell death Apoptosis Hu antigens ANNA-1 ANNA-2;

机译：副肿瘤综合征;抗Hu抗体;抗Ri抗体;神经元;脑切片培养;器官型脑培养;细胞死亡;细胞凋亡;Hu抗原ANNA-1;ANNA-2;

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专利

1. Neuronal uptake of anti-Hu antibody, but not anti-Ri antibody, leads to cell death in brain slice cultures [J] . John E Greenlee, Susan A Clawson, Kenneth E Hill, Journal of neuroinflammation . 2014,第1期

机译：神经元摄取抗Hu抗体而不是抗Ri抗体会导致脑切片培养物中的细胞死亡
2. Neuronal uptake of anti-Hu antibody, but not anti-Ri antibody, leads to cell death in brain slice cultures [J] . John E Greenlee, Susan A Clawson, Kenneth E Hill, Journal of neuroinflammation . 2014,第3期

机译：神经元摄取抗Hu抗体而不是抗Ri抗体会导致脑切片培养物中的细胞死亡
3. Purkinje Cell Death After Uptake of Anti-Yo Antibodies in Cerebellar Slice Cultures [J] . John E Greenlee Susan A Clawson Kenneth E Hill Blair L Wood Ikuo Tsunoda Noel G Carlson Journal of Neuropathology and Experimental Neurology . 2010,第10期

机译：小脑切片培养物中摄取抗Yo抗体后浦肯野细胞死亡
4. Uric acid prevents traumatic cell death and neuronal dysfunction in organotypic hippocampal slice cultures [C] . Goletiani C., Morrison B. IEEE Annual Northeast Bioengineering Conference . 2010

机译：尿酸预防器官型海马切片培养中的创伤性细胞死亡和神经元功能障碍
5. A novel type of cell death of lymphocytes induced by a monoclonal antibody against cell surface antigens without participation of complement利用統計を見る [D] . Matsuoka Shuji 1993

机译：没有补体参与的针对细胞表面抗原的单克隆抗体诱导的新型淋巴细胞细胞死亡
6. Anti-Yo Antibody Uptake and Interaction with Its Intracellular Target Antigen Causes Purkinje Cell Death in Rat Cerebellar Slice Cultures: A Possible Mechanism for Paraneoplastic Cerebellar Degeneration in Humans with Gynecological or Breast Cancers [O] . John E. Greenlee, Susan A. Clawson, Kenneth E. Hill, -1

机译：抗Yo抗体的摄取及其与细胞内靶抗原的相互作用导致大鼠小脑切片培养物中的浦肯野细胞死亡：妇科或乳腺癌患者副肿瘤小脑变性的可能机制
7. Neuronal uptake of anti-Hu antibody, but not anti-Ri antibody, leads to cell death in brain slice cultures [O] . 2014

机译：神经元摄取抗Hu抗体而不是抗Ri抗体会导致脑切片培养物中的细胞死亡

Neuronal uptake of anti-Hu antibody but not anti-Ri antibody leads to cell death in brain slice cultures

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