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首页> 美国卫生研究院文献>Experimental and Therapeutic Medicine >Impact of local administration of various doses of dexmedetomidine on ropivacaine-induced lumbar plexus-sciatic nerve block
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Impact of local administration of various doses of dexmedetomidine on ropivacaine-induced lumbar plexus-sciatic nerve block

机译：局部给药不同剂量右美托咪定对罗哌卡因诱导的腰丛-坐骨神经阻滞的影响

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摘要

The present study aimed to investigate the impact of various doses of dexmedetomidine (DEX) on ropivacaine (ROP)-induced lumbar plexus-sciatic nerve block (LSB). A total of 80 patients who underwent ankle surgery under LSB were divided into group R (applied with 30 ml 5% ROP), Dex1 (30 ml 0.5% ROP + 1 µg/kg DEX), Dex2 (30 ml 0.5% ROP + 1.5 µg/kg DEX) and Dex3 (30 ml 0.5% ROP + 2 µg/kg DEX), with 20 cases in each group. The onset time and duration of sensory and motor block, mean arterial pressure (MAP), heart rate (HR), oxygen saturation, Ramsay score, serum vascular endothelial growth factor (VEGF) level and adverse reactions in the four groups were observed. Results demonstrated that the durations of sensory and motor block in group R were shorter than those in groups Dex1-3 (P<0.01), followed by the sequence of group Dex1<Dex2<Dex3 (P<0.05). MAP and HR in groups Dex1-3 at T2-T5 were significantly lower than those in group R (P<0.01), and HR in group Dex3 at T3 and T4 was significantly lower than that in groups Dex1 and Dex2 (P<0.05). Ramsay scores in groups Dex1-3 at T2-T4 were significantly higher than those in group R (P<0.05). Serum VEGF levels in groups Dex2 and Dex3 at T2-T5 were significantly higher than those in group R (P<0.01). The incidences of over-sedation, bradycardia and dry mouth in group Dex3 were notably higher than those in the other groups. In conclusion, 1.5 µg/kg DEX exhibits a superior effect in improving ROP-induced LSB.
机译：本研究旨在研究不同剂量的右美托咪定（DEX）对罗哌卡因（ROP）诱导的腰丛-坐骨神经阻滞（LSB）的影响。将80名在LSB下进行踝关节手术的患者分为R组（应用30 ml 5％ROP），Dex1（30 ml 0.5％ROP +1μg/ kg DEX），Dex2（30 ml 0.5％ROP + 1.5）微克/千克DEX）和Dex3（30毫升0.5％ROP + 2微克/千克DEX），每组20例。观察四组患者的感觉和运动阻滞的发作时间和持续时间，平均动脉压（MAP），心率（HR），血氧饱和度，Ramsay评分，血清血管内皮生长因子（VEGF）水平和不良反应。结果表明，R组的感觉和运动阻滞持续时间短于Dex1-3组（P <0.01），其次是Dex1

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