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首页> 美国卫生研究院文献>Genetic Testing and Molecular Biomarkers >Association Study of Apolipoprotein L-I Lys166Glu and Ile244Met Gene Variants with Obesity in Chinese Subjects
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Association Study of Apolipoprotein L-I Lys166Glu and Ile244Met Gene Variants with Obesity in Chinese Subjects

机译：载脂蛋白L-1 Lys166Glu和Ile244Met基因变异与肥胖在中国人群中的相关性研究

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Aims: ApoL-I is a newly found component of high-density lipoprotein, and has a potential role in lipid metabolism. This study was mainly to examine the possible association of the ApoL-I gene polymorphism with obesity and plasma lipid levels in the Chinese population. Methods: Three hundred nineteen Han Chinese (109 obese and 210 nonobese control subjects) in Chengdu area were studied using polymerase chain reaction-restriction fragment length polymorphism analysis. Results: The Lys and Glu allele frequencies of the apoL-I gene at the Lys166Glu site in obese and nonobese control groups were 0.830, 0.170 and 0.814, 0.186, respectively. The Ile and Met allele frequencies of the gene at Ile244Met site in the obese and the control groups were 0.844, 0.156 and 0.831, 0.169, respectively. The 166Glu and 244Met allele frequencies of the two polymorphisms in obese subjects were not different from those in the controls, respectively (p>0.05). In the nonobese group, subjects with genotype Lys/Lys at the Lys166Glu site or Ile/Ile at the Ile244Met site had a higher serum mean concentration of triglyceride (TG) as compared with those of corresponding Glu or Met allele carriers (p<0.05). In addition, serum apoC-III and apoE levels were affected by genotypes of Lys166Glu and Ile224Met polymorphisms, respectively, in the control group (all p<0.05). Conclusion: The current study, for the first time, provides evidence that Lys166Glu and Ile244Met polymorphisms in apoL-I gene are associated with TG, apoC-III, and apoE levels in nonobese Chinese. However, these polymorphisms are not associated with obesity in the population.
机译：目的：ApoL-1是新发现的高密度脂蛋白成分，在脂质代谢中具有潜在作用。这项研究主要是为了研究中国人群中ApoL-I基因多态性与肥胖和血浆脂质水平的可能关系。方法：采用聚合酶链反应-限制性片段长度多态性分析方法，对成都地区119例汉族（109例肥胖者和210例非肥胖者）进行了研究。结果：肥胖和非肥胖对照组中，Lys166Glu位点的apoL-1基因的Lys和Glu等位基因频率分别为0.830、0.170和0.814、0.186。肥胖组和对照组的Ile244Met位点的基因的Ile和Met等位基因频率分别为0.844、0.156和0.831、0.169。肥胖受试者中两个多态性的166Glu和244Met等位基因频率分别与对照组无差异（p> 0.05）。在非肥胖组中，与相应的Glu或Met等位基因携带者相比，在Lys166Glu位点具有Lys / Lys或在Ile244Met位点具有Ile / Ile的基因型的受试者的甘油三酸酯（TG）血清平均浓度更高（p <0.05） 。另外，对照组的血清apoC-III和apoE水平分别受Lys166Glu和Ile224Met基因多态性的影响（均p <0.05）。结论：本研究首次提供证据，证明非肥胖中国人apoL-I基因的Lys166Glu和Ile244Met多态性与TG，apoC-III和apoE水平相关。但是，这些多态性与人群中的肥胖无关。

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