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首页> 美国卫生研究院文献>Experimental and Therapeutic Medicine >Soluble toll-like receptor 4 reversed attenuating effect of Chinese herbal Xiao-Qing-Long-Tang on allergen induced nerve growth factor and thymic stromal lymphopoietin
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Soluble toll-like receptor 4 reversed attenuating effect of Chinese herbal Xiao-Qing-Long-Tang on allergen induced nerve growth factor and thymic stromal lymphopoietin

机译：可溶性Toll样受体4逆转中草药小青龙汤对过敏原诱导的神经生长因子和胸腺基质淋巴细胞生成素的减毒作用

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Xiao-Qing-Long-Tang (XQLT) is known to regulate allergic immune reactions. The aim of this study was to investigate the effects of XQLT on allergen-induced cytokines and associated signaling pathways. An acute allergic mouse model was used to investigate the effects of XQLT on nerve growth factor (NGF) during an allergic reaction, while human pulmonary alveolar epithelial cells (HPAEpiCs) were used to investigate the effects of XQLT on Dermatophagoides pteronyssinus group 2 (Der p 2)-induced NGF, p75 neurotrophin receptor (p75NTR) and thymic stromal lymphopoietin (TSLP) expression. XQLT was demonstrated to inhibit NGF- and p75NTR-related allergic reactions in the mouse model. XQLT also reduced the expression of Toll-like receptor 4 (TLR4) in the lungs of the model mice. XQLT inhibited Der p 2-induced NGF, TSLP and p75NTR expression in the HPAEpiC cell line. The use of recombinant soluble TLR4 (sTLR4) in a competitive assay partially attenuated the inhibitory effect of XQLT on NGF, TSLP and p75NTR expression in HPAEpiC cells. The inhibitory effect of XQLT on the Ser536 phosphorylation of p65 (nuclear factor-κB; NF-κB), a TLR4-induced factor, was also attenuated by sTLR4. In conclusion, XQLT inhibited Der p allergen-induced NGF, p75NTR and TSLP expression. This inhibition was attenuated by sTLR4. The mechanism of action of XQLT may be correlated with TLR4, a primary receptor in the innate immune system. The findings of this study may focus the search for pharmacological targets of XQLT onto TLR4, which is important in the allergen presentation pathway.
机译：小青龙汤（XQLT）可以调节过敏性免疫反应。这项研究的目的是调查XQLT对变应原诱导的细胞因子及相关信号通路的影响。急性过敏性小鼠模型用于研究XQLT对过敏反应过程中神经生长因子（NGF）的影响，而人类肺泡上皮细胞（HPAEpiCs）用于研究XQLT对2类蕨类植物Dermatophagoides pteronyssinus（Der p 2）诱导NGF，p75神经营养蛋白受体（p75NTR）和胸腺基质淋巴细胞生成素（TSLP）的表达。在小鼠模型中，XQLT被证明可以抑制NGF和p75NTR相关的过敏反应。 XQLT还降低了模型小鼠肺中Toll样受体4（TLR4）的表达。 XQLT抑制HPAEpiC细胞系中Der p 2诱导的NGF，TSLP和p75NTR表达。在竞争性测定中重组可溶性TLR4（sTLR4）的使用部分减弱了XQLT对HPAEpiC细胞中NGF，TSLP和p75NTR表达的抑制作用。 XQLT对TLR4诱导的因子p65（核因子-κB；NF-κB）的Ser536磷酸化的抑制作用也被sTLR4减弱。总之，XQLT抑制Der p过敏原诱​​导的NGF，p75NTR和TSLP表达。 sTLR4减弱了这种抑制作用。 XQLT的作用机制可能与先天免疫系统中的主要受体TLR4有关。这项研究的发现可能会将XQLT的药理靶点集中在TLR4上，这在过敏原呈递途径中很重要。

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