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首页> 美国卫生研究院文献>International Journal of Epidemiology >Maternal pre-pregnancy body mass index and offspring attention deficit hyperactivity disorder: a population-based cohort study using a sibling-comparison design
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Maternal pre-pregnancy body mass index and offspring attention deficit hyperactivity disorder: a population-based cohort study using a sibling-comparison design

机译：孕前孕妇体重指数和后代注意缺陷多动障碍：使用同胞比较设计的基于人群的队列研究

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>Background High maternal pre-pregnancy body mass index (BMI) is associated with increased risk of offspring attention deficit hyperactivity disorder (ADHD). However, the role of unmeasured familial confounding for this association remains unclear.>Methods We conducted a population-based cohort study via linkage of Swedish national and regional registers to investigate maternal pre-pregnancy BMI (underweight: BMI <18.5; overweight: 25≤ BMI <30; obesity: BMI ≥30) in relation to offspring ADHD. We followed 673 632 individuals born in Sweden between 1992 and 2000, with prospectively collected information on maternal pre-pregnancy BMI, until they received an ADHD diagnosis or ADHD medication, death, emigration or 31 December 2009. Hazard ratios (HRs) were estimated by Cox proportional hazards models. Stratified Cox proportional hazards models were applied to data on full siblings to control for unmeasured familial confounding.>Results At the population level, pre-pregnancy overweight/obesity was associated with increased risk of offspring ADHD (HRoverweight = 1.23, 95% CI = 1.18–1.27, P = 0.01; HRobesity = 1.64, 95% CI = 1.57–1.73, P = 0.01), after adjustment for measured covariates. In full sibling comparisons, however, previously observed associations no longer remained (HRoverweight = 0.98, 95% CI = 0.83–1.16, P = 0.82; HRobesity = 1.15, 95% CI = 0.85–1.56, P = 0.38).>Conclusions The results suggested that the association between maternal pre-pregnancy overweight/obesity and offspring ADHD could be ascribed to unmeasured familial confounding.
机译：>背景母亲孕前体重指数（BMI）高与后代注意力不足多动障碍（ADHD）风险增加有关。但是，尚不清楚家族性混杂因素在该协会中的作用。>方法。我们通过瑞典国家和地区登记处的联系进行了一项基于人群的队列研究，以调查孕前BMI（体重过轻：BMI < 18.5；超重：25≤BMI <30；肥胖：BMI≥30）与后代ADHD有关。我们追踪了1992年至2000年在瑞典出生的673632个人，对他们的孕前BMI进行了前瞻性收集，直到他们接受了ADHD诊断或ADHD药物治疗，死亡，移民或2009年12月31日为止。危险比（HRs）由考克斯比例风险模型。 >结果在人群一级，孕前超重/肥胖与后代多动症风险增加相关（HR超重= 1.23） ，对测量的协变量进行校正后，95％CI = 1.18–1.27，P = 0.01； HRobesity = 1.64，95％CI = 1.57–1.73，P = 0.01）。但是，在完全同级比较中，以前观察到的关联不再存在（HR超重= 0.98，95％CI = 0.83-1.16，P = 0.82； HRobesity = 1.15，95％CI = 0.85-1.56，P = 0.38）。>结论研究结果表明，孕妇孕前超重/肥胖与后代多动症之间的相关性可能归因于无法衡量的家族混杂。

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