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首页> 外文期刊>International Journal of Epidemiology: Official Journal of the International Epidemiological Association >Maternal pre-pregnancy body mass index and offspring attention deficit hyperactivity disorder: A population-based cohort study using a sibling-comparison design
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Maternal pre-pregnancy body mass index and offspring attention deficit hyperactivity disorder: A population-based cohort study using a sibling-comparison design

机译：孕前孕妇体重指数和后代注意缺陷多动障碍：使用同胞比较设计的基于人群的队列研究

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Background: High maternal pre-pregnancy body mass index (BMI) is associated with increased risk of offspring attention deficit hyperactivity disorder (ADHD). However, the role of unmeasured familial confounding for this association remains unclear. Methods: We conducted a population-based cohort study via linkage of Swedish national and regional registers to investigate maternal pre-pregnancy BMI (underweight: BMI 18.5; overweight: 25 ≤ BMI 30; obesity: BMI ≥30) in relation to offspring ADHD. We followed 673 632 individuals born in Sweden between 1992 and 2000, with prospectively collected information on maternal prepregnancy BMI, until they received an ADHD diagnosis or ADHD medication, death, emigration or 31 December 2009. Hazard ratios (HRs) were estimated by Cox proportional hazards models. Stratified Cox proportional hazards models were applied to data on full siblings to control for unmeasured familial confounding. Results: At the population level, pre-pregnancy overweight/obesity was associated with increased risk of offspring ADHD (HRoverweight=1.23, 95% CI=1.18-1.27, P=0.01; HRobesity=1.64, 95% CI=1.57-1.73, P=0.01), after adjustment for measured covariates. In full sibling comparisons, however, previously observed associations no longer remained (HRoverweight=0.98, 95% CI=0.83-1.16, P=0.82; HRobesity=1.15, 95% CI=0.85-1.56, P=0.38). Conclusions: The results suggested that the association between maternal prepregnancy overweight/obesity and offspring ADHD could be ascribed to unmeasured familial confounding.
机译：背景：高孕妇产前体重指数（BMI）与后代注意力不足过动症（ADHD）的风险增加有关。但是，尚不清楚家族性混杂因素在该协会中的作用。方法：我们通过瑞典国家和地区登记册进行了一项基于人群的队列研究，以调查与后代有关的孕前BMI（体重不足：BMI <18.5;超重：25≤BMI <30;肥胖：BMI≥30）多动症。我们追踪了1992年至2000年在瑞典出生的673632个人，前瞻性地收集了有关孕前BMI的信息，直到他们接受了ADHD诊断或ADHD药物治疗，死亡，移民或2009年12月31日为止。危险比（HRs）由Cox比例估算危害模型。将分层Cox比例风险模型应用于全兄弟姐妹的数据，以控制未测的家庭混杂因素。结果：在人群水平上，孕前超重/肥胖与后代多动症风险增加相关（HR超重= 1.23，95％CI = 1.18-1.27，P = 0.01; HRobesity = 1.64，95％CI = 1.57-1.73， P = 0.01），针对测量的协变量进行调整后。然而，在完整的同级比较中，以前观察到的关联不再存在（HR超重= 0.98，95％CI = 0.83-1.16，P = 0.82; HRobesity = 1.15，95％CI = 0.85-1.56，P = 0.38）。结论：研究结果表明，孕前超重/肥胖与后代多动症之间的关联可能归因于无法测量的家族性混杂。

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