首页> 美国卫生研究院文献>Journal of Bone and Mineral Research >Osteoporosis Screening in Postmenopausal Women 50-64 years-old: Comparison of U.S. Preventive Services Task Force Strategy and Two Traditional Strategies in the Womens Health Initiative
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Osteoporosis Screening in Postmenopausal Women 50-64 years-old: Comparison of U.S. Preventive Services Task Force Strategy and Two Traditional Strategies in the Womens Health Initiative

机译:50-64岁绝经后妇女的骨质疏松症筛查:美国预防服务工作队策略与妇女健康计划中的两种传统策略的比较

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摘要

The U.S. Preventive Services Task Force (USPSTF) recommends osteoporosis screening for women younger than 65 years whose 10-year predicted risk of major osteoporotic fracture is ≥ 9.3%. For identifying screening candidates among women aged 50-64 years, it is uncertain how the USPSTF strategy compares with the Osteoporosis Self-Assessment Tool (OST) and the Simple Calculated Osteoporosis Risk Estimate (SCORE). We examined data (1994-2012) from 5165 Women's Health Initiative participants aged 50-64. For the USPSTF (FRAX major fracture risk ≥ 9.3% calculated without BMD), OST (score <2), and SCORE (score >7) strategies, we assessed sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) to discriminate between those with and without femoral neck (FN) T-score ≤ −2.5. Sensitivity, specificity, and AUC for identifying FN T-score ≤ −2.5 were 34.1%, 85.8%, and 0.60 for USPSTF (FRAX), 74.0%, 70.8%, and 0.72 for SCORE, and 79.8%, 66.3%, and 0.73 for OST. The USPSTF strategy identified about 1/3rd of women aged 50-64 with FN T-scores ≤ −2.5. Among women aged 50-64 years, the USPSTF strategy was modestly better than chance alone and inferior to conventional SCORE and OST strategies in discriminating between women with and without FN T-score ≤ −2.5.
机译:美国预防服务工作队(USPSTF)建议对65岁以下的女性进行骨质疏松症筛查,其10年预测的严重骨质疏松性骨折风险≥9.3%。为了确定年龄在50-64岁之间的女性的筛查对象,尚不确定USPSTF策略如何与骨质疏松症自我评估工具(OST)和简单计算的骨质疏松症风险评估(SCORE)进行比较。我们研究了5165位年龄在50-64岁之间的“妇女健康倡议”参与者的数据(1994-2012年)。对于USPSTF(未使用BMD计算得出的FRAX重大骨折风险≥9.3%),OST(评分<2)和SCORE(评分> 7)策略,我们评估了接受者工作特征曲线(AUC)下的敏感性,特异性和面积区分有和没有股骨颈(FN)的T分数≤-2.5。鉴定FN T分数≤-2.5的灵敏度,特异性和AUC(USPSTF(FRAX))分别为34.1%,85.8%和0.60,SCORE为74.0%,70.8%和0.72,79.8%,66.3%和0.73对于OST。 USPSTF策略确定了FN T分数≤-2.5的50-64岁女性中约有1/3 rd 。在50-64岁的女性中,USPSTF策略比单独的机会策略略胜一筹,并且在区分FN T分数≤-2.5和不具有FN T分数的女性方面不如传统的SCORE和OST策略。

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