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首页> 美国卫生研究院文献>Scientific Reports >In vitro Evaluation of Porous borosilicate borophosphate and phosphate Bioactive Glasses Scaffolds fabricated using Foaming Agent for Bone Regeneration
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In vitro Evaluation of Porous borosilicate borophosphate and phosphate Bioactive Glasses Scaffolds fabricated using Foaming Agent for Bone Regeneration

机译：泡沫再生剂制备的多孔硼硅酸盐硼磷酸盐和磷酸盐生物活性玻璃支架的体外评估

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In this work, glasses within the borosilicate borophosphate and phosphate family were sintered into 3D porous scaffolds using 60 and 70 vol. % NH4(HCO3) as a foaming agent. All scaffolds produced remained amorphous; apart from one third of the glasses which crystallized. All produced scaffolds had porosity >50% and interconnected pores in the range of 250–570 µm; as evidenced by µCT. The in-vitro dissolution of the scaffolds in SBF and changes in compression were assessed as a function of immersion time. The pH of the solution containing the borosilicate scaffolds increased due to the typical non-congruent dissolution of this glass family. Borophosphate and phosphate scaffolds induced a decrease in pH upon dissolution attributed to the congruent dissolution of those materials and the large release of phosphate within the media. As prepared, scaffolds showed compressive strength of 1.29 ± 0.21, 1.56 ± 0.63, 3.63 ± 0.69 MPa for the borosilicate, borophosphate and phosphate samples sintered with 60 vol. % NH4 (HCO3), respectively. Evidence of hydroxyapatite precipitation on the borosilicate glass scaffolds was shown by SEM/EDS, XRD and ICP-OES analysis. The borophosphate scaffolds remained stable upon dissolution. The phosphate scaffolds were fully crystallized, leading to very large release of phosphate in the media.
机译：在这项工作中，使用60和70 vol的硼硅酸盐，硼磷酸盐和磷酸盐家族中的玻璃被烧结成3D多孔支架。 ％NH4（HCO3）作为发泡剂。产生的所有支架都保持无定形。除了三分之一的结晶玻璃。所有生产的脚手架的孔隙率均大于50％，相互连接的孔隙范围为250-570微米。由µCT证明。评估支架在SBF中的体外溶出度和压迫力变化与浸入时间的关系。含有硼硅酸盐支架的溶液的pH值由于该玻璃族的典型非同质溶解而增加。硼磷酸盐和磷酸盐支架在溶解时引起pH降低，这归因于这些物质的完全溶解以及培养基中磷酸盐的大量释放。如制备的，对于以60vol。％烧结的硼硅酸盐，硼磷酸盐和磷酸盐样品，支架显示出1.29±0.21、1.56±0.63、3.63±0.69 MPa的抗压强度。分别为NH4（HCO3）％。通过SEM / EDS，XRD和ICP-OES分析显示了羟基磷灰石在硼硅酸盐玻璃支架上沉淀的证据。硼磷酸盐支架在溶解后保持稳定。磷酸盐支架完全结晶，导致磷酸盐在培养基中大量释放。

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