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首页> 外文会议>Materials Science and Technology Conference >EVALUATION OF LONG-TERM BONE REGENERATION IN RAT CALVARIAL DEFECTS IMPLANTED WITH STRONG POROUS BIOACTIVE GLASS (13-93) SCAFFOLDS
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EVALUATION OF LONG-TERM BONE REGENERATION IN RAT CALVARIAL DEFECTS IMPLANTED WITH STRONG POROUS BIOACTIVE GLASS (13-93) SCAFFOLDS

机译：用强孔生物活性玻璃（13-93）支架植入大鼠颅骨缺陷中长期骨再生的评价

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摘要

The use of bioactive glass scaffolds for repairing large bone defects, particularly in structural bone, is an area of increasing interest. However, data on the capacity of bioactive glass scaffolds to regenerate bone in vivo over a long-term duration are limited. In this study, bone regeneration in rat calvarial defects implanted with strong porous scaffolds of silicate 13-93 glass (porosity = 47 ± 1%) was investigated at 6, 12 and 24 weeks postimplantation. Two groups of implants, composed of as-fabricated scaffolds and scaffolds loaded with bone morphogenetic protein-2 (BMP2) (1 μg/defect) were studied. Bone regeneration and bioactive glass conversion to hydroxyapatite in the defects implanted with the two groups of scaffolds were evaluated using histology, histomorphometric analysis and scanning electron microscopy. When compared to the as-fabricated scaffolds, the BMP2-loaded scaffolds showed significantly better capacity to regenerate bone at all three implantation times and they were almost completely infiltrated with lamellar bone within 12 weeks. The amount of glass conversion to hydroxyapatite at 24 weeks (～30%) was not significantly different between the two groups of scaffolds. Based on their capacity to rapidly regenerate bone and to maintain healthy bone growth over the 24 week period, these strong porous bioactive glass (13-93) scaffolds loaded with BMP2 are promising candidate implants for structural bone repair.
机译：使用生物活性玻璃支架来修复大骨缺陷，特别是在结构骨中，是越来越感兴趣的区域。然而，关于生物活性玻璃支架的能力在长期持续时间内体内生物活性玻璃支架以再生骨的数据有限。在本研究中，在后期后，研究了植入硅酸盐13-93玻璃（孔隙率= 47±1％）的强烈多孔支架的大鼠颅骨缺陷中的骨再生。研究了两组植入物，由由骨形态发生蛋白-2（BMP2）（1μg/缺陷）的制造的支架和支架组成。使用组织学，组织学分析和扫描电子显微镜评估骨再生和生物活性玻璃转化对植入两组支架的缺陷中的羟基磷灰石。与制造的支架相比，BMP2装载的支架在所有三个植入时间上显示出骨骼的显着更好的能力，并且在12周内几乎用层状骨完全渗透。两组支架之间24周（〜30％）在24周（〜30％）对羟基磷灰石的量没有显着差异。基于它们在24周内快速再生骨骼和保持健康骨骼生长的能力，这些强烈的多孔生物活性玻璃（13-93）用BMP2负载的支架是有前途的候选植入物，用于结构骨骼修复。

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