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首页> 外文期刊>Journal of Non-Crystalline Solids: A Journal Devoted to Oxide, Halide, Chalcogenide and Metallic Glasses, Amorphous Semiconductors, Non-Crystalline Films, Glass-Ceramics and Glassy Composites >Long-term bone regeneration, mineralization and angiogenesis in rat calvarial defects implanted with strong porous bioactive glass (13-93) scaffolds
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Long-term bone regeneration, mineralization and angiogenesis in rat calvarial defects implanted with strong porous bioactive glass (13-93) scaffolds

机译：植入强多孔生物活性玻璃（13-93）支架的大鼠颅骨缺损的长期骨再生，矿化和血管生成

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There is growing interest in the use of bioactive glass scaffolds for repairing structural bone defects but data on the capacity of the scaffolds to regenerate bone in vivo, particularly over a long-term duration, are limited. In this study, bone regeneration in rat calvarial defects implanted with strong porous scaffolds of silicate 13-93 glass (porosity = 47 +/- 1%) was investigated at 12 and 24 weeks post-implantation and compared with previous results from a similar study at 6 weeks. Three groups of implants, composed of as-fabricated scaffolds, scaffolds pretreated in a phosphate solution to convert a thin surface layer (5 mu m) to hydroxyapatite (HA) and pretreated scaffolds loaded with bone morphogenetic protein-2 (BMP2) (1 mu g/defect) were used. Bone regeneration, bioactive glass conversion to HA and blood vessel formation in the defects implanted with the three groups of scaffolds were evaluated using histology, histomorphometric analysis and scanning electron microscopy. When compared to the as-fabricated scaffolds, the pretreated scaffolds enhanced bone regeneration at 6 weeks but not at 12 or 24 weeks. In comparison, the BMP2-loaded scaffolds showed a significantly better capacity to regenerate bone at all three implantation times and they were almost completely infiltrated with lamellar bone within 12 weeks. The amount of glass conversion to HA at 24 weeks (30-33%) was not significantly different among the three groups of scaffolds. The area and number of blood vessels in the new bone that infiltrated the BMP2-loaded scaffolds at 6 and 12 weeks postimplantation were significantly greater than those for the as-fabricated and pretreated scaffolds. However, there was no significant difference in blood vessel area and number among the three groups of scaffolds at 24 weeks. The results indicate that these strong porous bioactive glass (13-93) scaffolds loaded with BMP2 are promising candidate implants for structural bone repair. (C) 2015 Elsevier B.V. All rights reserved.
机译：使用生物活性玻璃支架修复结构性骨缺损的兴趣日益增长，但是有关支架在体内，尤其是在长期内再生骨骼的能力的数据有限。在这项研究中，在植入后第12和24周研究了植入有强力多孔硅酸盐13-93玻璃（孔隙度= 47 +/- 1％）的大鼠颅骨缺损的骨再生，并将其与以前类似研究的结果进行了比较。在6周。三组植入物，由预制的支架组成，在磷酸盐溶液中预处理以将薄表面层（5μm）转化为羟基磷灰石（HA）的支架，以及预处理的负载骨形态发生蛋白2（BMP2）的支架（1 mu g /缺陷）。使用组织学，组织形态计量学分析和扫描电子显微镜，评估了植入三组支架的缺损中的骨再生，生物活性玻璃向HA的转化以及血管形成。与制成的支架相比，经过预处理的支架可在6周时增强骨骼再生，而在12周或24周时则不增强。相比之下，负载BMP2的支架在所有三个植入时间均显示出明显更好的再生骨能力，并且在12周内几乎完全被片状骨浸润。三组支架在24周时玻璃转化为HA的量（30-33％）没有显着差异。植入后6周和12周时，新骨中渗入BMP2支架的血管的面积和数量显着大于预制和预处理的支架。然而，在24周时，三组支架之间的血管面积和数量没有显着差异。结果表明，这些装有BMP2的坚固多孔生物活性玻璃（13-93）支架是用于结构性骨修复的有前途的候选植入物。 （C）2015 Elsevier B.V.保留所有权利。

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