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首页> 美国卫生研究院文献>Scientific Reports >RNA-Seq Analyses Identify Frequent Allele Specific Expression and No Evidence of Genomic Imprinting in Specific Embryonic Tissues of Chicken
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RNA-Seq Analyses Identify Frequent Allele Specific Expression and No Evidence of Genomic Imprinting in Specific Embryonic Tissues of Chicken

机译：RNA序列分析确定频繁的等位基因特异性表达没有证据表明鸡特定胚胎组织中的基因组印记

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Epigenetic and genetic cis-regulatory elements in diploid organisms may cause allele specific expression (ASE) – unequal expression of the two chromosomal gene copies. Genomic imprinting is an intriguing type of ASE in which some genes are expressed monoallelically from either the paternal allele or maternal allele as a result of epigenetic modifications. Imprinted genes have been identified in several animal species and are frequently associated with embryonic development and growth. Whether genomic imprinting exists in chickens remains debatable, as previous studies have reported conflicting evidence. Albeit no genomic imprinting has been reported in the chicken embryo as a whole, we interrogated the existence or absence of genomic imprinting in the 12-day-old chicken embryonic brain and liver by examining ASE in F1 reciprocal crosses of two highly inbred chicken lines (Fayoumi and Leghorn). We identified 5197 and 4638 ASE SNPs, corresponding to 18.3% and 17.3% of the genes with a detectable expression in the embryonic brain and liver, respectively. There was no evidence detected of genomic imprinting in 12-day-old embryonic brain and liver. While ruling out the possibility of imprinted Z-chromosome inactivation, our results indicated that Z-linked gene expression is partially compensated between sexes in chickens.
机译：二倍体生物中的表观遗传和遗传顺式调控元件可能导致等位基因特异性表达（ASE）–两个染色体基因拷贝的表达不相等。基因组印迹是一种引人入胜的ASE类型，其中由于表观遗传修饰，一些基因从父本等位基因或母本等位基因单等位基因表达。已在几种动物物种中鉴定出印迹基因，这些基因通常与胚胎发育有关。由于先前的研究报道了相互矛盾的证据，因此在鸡中是否存在基因组印记仍有待商bat。尽管尚未在整个鸡胚中报告基因组印记，但我们通过检查两个高度近交鸡系的F1倒交杂交中的ASE来询问12天大的鸡胚脑和肝脏中是否存在基因组印记（ Fayoumi和Leghorn）。我们鉴定出5197个和4638个ASE SNP，分别对应于在胚胎脑和肝脏中可检测到表达的基因的18.3％和17.3％。没有证据表明在12天大的胚胎脑和肝脏中有基因组印迹。在排除印迹Z染色体失活的可能性的同时，我们的结果表明Z连锁基因的表达在鸡的性别之间得到了部分补偿。

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