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首页> 美国卫生研究院文献>Scientific Reports >Efficacy of species-specific protein antibiotics in a murine model of acute Pseudomonas aeruginosa lung infection
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Efficacy of species-specific protein antibiotics in a murine model of acute Pseudomonas aeruginosa lung infection

机译：物种特异性蛋白抗生素在急性铜绿假单胞菌肺部感染小鼠模型中的功效

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Protein antibiotics, known as bacteriocins, are widely produced by bacteria for intraspecies competition. The potency and targeted action of bacteriocins suggests that they could be developed into clinically useful antibiotics against highly drug resistant Gram-negative pathogens for which there are few therapeutic options. Here we show that Pseudomonas aeruginosa specific bacteriocins, known as pyocins, show strong efficacy in a murine model of P. aeruginosa lung infection, with the concentration of pyocin S5 required to afford protection from a lethal infection at least 100-fold lower than the most commonly used inhaled antibiotic tobramycin. Additionally, pyocins are stable in the lung, poorly immunogenic at high concentrations and efficacy is maintained in the presence of pyocin specific antibodies after repeated pyocin administration. Bacteriocin encoding genes are frequently found in microbial genomes and could therefore offer a ready supply of highly targeted and potent antibiotics active against problematic Gram-negative pathogens.
机译：蛋白细菌被称为细菌素，广泛用于细菌之间的种内竞争。细菌素的效力和针对性作用表明，它们可以被开发为对高度耐药的革兰氏阴性病原体具有临床选择的抗生素，而对于这些细菌而言，治疗选择很少。在这里，我们显示铜绿假单胞菌特有的细菌素，称为脓菌素，在铜绿假单胞菌肺部感染的鼠模型中显示出强大的功效，提供能够抵抗致命性感染的保护作用的脓毒素S5的浓度比大多数情况低至少100倍。常用吸入抗生素妥布霉素。另外，脓毒蛋白在肺中是稳定的，在高浓度下免疫原性差，并且在反复施用脓毒素后，在存在脓毒素特异性抗体的情况下仍保持功效。细菌素编码基因通常在微生物基因组中发现，因此可以提供对有问题的革兰氏阴性病原体具有活性的高度靶向和有效的抗生素。

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